January 2023 | LCGC North America

What Are My Options to Improve My Separation? Part I: Foundational Concepts

January 01, 2023

Column: LC Troubleshooting

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When considering different ways to improve an established LC method, it helps to start by reviewing some essential concepts.

Overview of Recent Development of Needle-Trap Devices for Analysis of Volatile Compounds

January 01, 2023

Column: Sample Prep Perspectives

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Continued development of needle-trap extraction (NTE) has expanded its versatility in applications such as disease diagnosis, aerosol-bound analytes, and breath analysis.

Does High Polarity Mean High Retention on Stationary Phases in Gas Chromatography?

January 01, 2023

Column: GC Connections

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The common measures of stationary phase polarity—McReynolds constants and the polarity scale—are not always accurate predictors of retentiveness or selectivity in GC.

Analytical Methods to Determine the Stability of Biopharmaceutical Products

January 01, 2023

Column: Focus on Biopharmaceutical Analysis

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A drug stability program is a fundamental part of ensuring product quality, safety, and efficacy. Here, we summarize essential guidelines, differences between large- and small-molecule stability, and the analytical methods used.

Viewpoints: The Rise of Automation—Evolve or Die?

January 01, 2023

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Robots outperform humans in five areas, and thus can be particularly beneficial for performing sample preparation for HPLC.

Harmonization of Experimental Methods Used to Measure the True Hold-Up Volume of Liquid Chromatography Columns

January 01, 2023

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A harmonization of all conventional hold-up volume methods was successfully applied to RPLC, HILIC, AEX, and RP-AEX mixed-mode chromatography, regardless of the mobile phase.