January 2023

When considering different ways to improve an established LC method, it helps to start by reviewing some essential concepts.

Continued development of needle-trap extraction (NTE) has expanded its versatility in applications such as disease diagnosis, aerosol-bound analytes, and breath analysis.

The common measures of stationary phase polarity—McReynolds constants and the polarity scale—are not always accurate predictors of retentiveness or selectivity in GC.

A drug stability program is a fundamental part of ensuring product quality, safety, and efficacy. Here, we summarize essential guidelines, differences between large- and small-molecule stability, and the analytical methods used.

Robots outperform humans in five areas, and thus can be particularly beneficial for performing sample preparation for HPLC.

A harmonization of all conventional hold-up volume methods was successfully applied to RPLC, HILIC, AEX, and RP-AEX mixed-mode chromatography, regardless of the mobile phase.