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LCGC North America-01-01-2015

LCGC North America

A New Look at Sample Prep

January 01, 2015

From the Editor

33

1

Quantifying Small Molecules by Mass Spectrometry

January 01, 2015

MS – The Practical Art

33

1

The use of a mass spectrometer in quantitative analysis exploits its exquisite selectivity and sensitivity as a detector, allowing a signal to be ascribed to a particular chemical entity with high certainty, even when present in a sample at a low concentration.

Challenges in the Determination of Protein Aggregates, Part I

January 01, 2015

Biotechnology Today

33

1

Most analytical approaches used for the determination of low-molecular-weight noncovalent aggregates in protein pharmaceuticals suffer from important limitations. This first part of this two-part column series discusses those limitations.

In Memoriam: Professor Georges A. Guiochon

January 01, 2015

Featured Article

33

1

On October 21, 2014, University of Tennessee Distinguished Scientist Georges Andre Guiochon succumbed to neuromuscular failure caused by post-polio syndrome. Here, we pay tribute to his remarkable career and life.

HPLC Detector Selection — What, Where, When, and How

January 01, 2015

The Essentials

33

1

The ideal UV detector would allow us to monitor the presence of our target analytes without influence from the background eluent and sample matrix components that may be present in the detector measuring cell at the same time

Large-Volume Injection LC–MS-MS Methods for Aqueous Samples and Organic Extracts

January 01, 2015

Peer-Reviewed Article

33

1

Environmental sample analysis by large-volume injection (LVI) in combination with liquid chromatography–tandem mass spectrometry (LC–MS-MS) is described for polar and nonpolar analytes in both aqueous samples and organic extracts.

Vol 33 No1 LCGC North America January 2015 Regular Issue PDF

January 01, 2015

Issue PDF

33

1

Click the title above to open the LCGC North America January 2015 regular issue, Vol 33 No 1, in an interactive PDF format.