The use of a mass spectrometer in quantitative analysis exploits its exquisite selectivity and sensitivity as a detector, allowing a signal to be ascribed to a particular chemical entity with high certainty, even when present in a sample at a low concentration.
Most analytical approaches used for the determination of low-molecular-weight noncovalent aggregates in protein pharmaceuticals suffer from important limitations. This first part of this two-part column series discusses those limitations.
On October 21, 2014, University of Tennessee Distinguished Scientist Georges Andre Guiochon succumbed to neuromuscular failure caused by post-polio syndrome. Here, we pay tribute to his remarkable career and life.
The ideal UV detector would allow us to monitor the presence of our target analytes without influence from the background eluent and sample matrix components that may be present in the detector measuring cell at the same time
Environmental sample analysis by large-volume injection (LVI) in combination with liquid chromatography–tandem mass spectrometry (LC–MS-MS) is described for polar and nonpolar analytes in both aqueous samples and organic extracts.