LCGC North America-10-01-2007

LCGC North America
LC Troubleshooting

October 01, 2007

How to avoid an expensive shot in the dark.

LCGC North America
Departments

October 01, 2007

Gas chromatography–mass spectrometry (GC–MS) is the most widespread tandem technique in the analytical instrumentation industry. In fact, these systems account for the largest installed base of mass spectrometry instruments.

LCGC North America

An ultrahigh-pressure liquid chromatography (UHPLC) method was developed to separate paroxetine from several of its related compounds using a systematic screening protocol that monitors combinations of selectivity factors including column chemistry, organic modifier, and pH. When the best combination of these factors was selected, the method was optimized by varying gradient slope and temperature.

LCGC North America

Quantitative assessment of protein expression in biological systems in response to perturbations is an important element in the discovery and validation of biomarkers and drug targets. This can be a challenging task given the complexity and dynamic range of biological extracts. Many methods are currently in use to address protein quantification. This installment of "Directions in Discovery" reviews several of the more popular ones and reports on a collaborative study organized by the Association of Biomolecular Resource Facilities.

LCGC North America
Column Watch Column

October 01, 2007

HPLC 2007 was held in Ghent, Belgium in June. Last month, columnist Ron Majors summarized some the important column developments as well as other Symposium highlights. This month, he winds up coverage with additional highlights in the areas of technology and applications. Among the topics covered are stationary phase preparation and characterization, multi-dimensional and comprehensive LC, temperature studies, detectors and an application overview.

LCGC North America
MS - The Practical Art

October 01, 2007

"As research advances, about half of what we will teach you . . . will turn out to be wrong. The problem is, we presently don't know which half." Powerful Medicines, Jerry Avorn, 2004

Departments
LCGC North America

October 01, 2007

Ron Majors awarded gold medal; Airgas acquires Dantack; Molex acquires Polymicro