LCGC North America-11-01-2006

Thar Technologies, Inc. (Pittsburgh, Pennsylvania) announced that it has entered into an agreement to develop supercritical fluid chromatography (SFC) applications with the Norwegian University of Life Sciences (As, Norway, NULS).

What do you do when the sample changes inside the column?

November 2006. This month, John Hinshaw addresses questions of instrument capabilities and chromatographers' expectations. In subsequent issues, he will discuss adjustment of hardware settings, optimization of column parameters, and data-handling issues. This is the first article in the recently released "GC Connections Resource Guide."

Measurement of chiral purity is a necessary means of quality control for drug substances that exhibit chiral centers. This article describes a simple and practical approach to setting up system suitability and validation for chiral purity assays.

November 2006. The objective of a formal method transfer is to ensure that the receiving laboratory is well trained, qualified to run the method in question, and gets the same results - within experimental error - as the initiating laboratory. The development and validation of robust methods and strict adherence to well documented standard operating procedures is the best way to ensure the ultimate success of the method. This installment of "Validation Viewpoint" examines the analytical method transfer process, including protocol, documentation, and some possible chromatographic pitfalls to avoid.

In any field there are often "misconceptions" or "myths" that are perpetuated and passed on to the next generation.

The laboratory life science and analytical instrument industry is comprised of a large, diverse group of organizations that manufacture and distribute their products worldwide. However, overall industry sales are concentrated among a small set of companies. Approximately 950 firms are included in the industry, but only about 100 companies have sales above $50 million.