Urinary excretion profiling is a key element in the pharmokinetic characterization of new chemical entities (NCEs). Recent advances in ultra-high performance liquid chromatography (UHPLC) column technology offer improved results for liquid chromatography tandem mass spectrometry (LC–MS¬–MS) analysis, enabling rapid quantification of specific drugs and their metabolites in biological matrices.
The Column spoke to Hans van den Heuvel, the Product Marketing Manager for Bruker Chemical & Applied Markets.
Malaria is the 5th responsible cause of death from infectious disease worldwide, and approximately half the global population are at risk. 1A team of scientists in Missouri, USA3 has recently answered a long-standing question regarding the metabolism of the parasite, advancing research towards identifying novel therapeutics
Drug bioavailability, the rate at which the active compound of a drug becomes available at the site of action, is key to the successful development of new drugs. The development of hydrogels, self-assembling polymer-based scaffolds, has rapidly accelerated in recent years because of their potential in the improvement of drug bioavailability.
Organophosphates (OPs) are commonly found in commercial pesticides and are highly toxic to humans if inhaled or ingested, resulting in both behavioural and psychological symptoms. OPs chemically modify the essential protein acetylcholine esterase, which is principally responsible for the breakdown of the essential neurotransmitter acetylcholine.
Incognito ruminates on the value of setting up a method from scratch.
In der Oktober-Ausgabe von LCGC Ausgabe in deutscher Sprache beschäftigen wir uns mit zertifizierten Referenzmaterialien und der Bedeutung von ISO Guide 34, sowohl für die Hersteller als auch für die Endverbraucher. Der regelmäßige Kolumnist von „GC-Verknüpfungen“, John V. Hinshaw, ergänzt seine Serie von Juni 2011 um eine weitere Folge und erörtert den Einsatz von Gasschaltventilen zur Säulen-Rückspülung und für zweidimensionale Serien-Bypass-Anwendungen.
Waters EU - Chiesi and Waters Implement a Lean, Paperless Lab
Karyn M. Usher of West Chester University of Pennsylvania interviews Phyllis R. Brown, professor emerita of the University of Rhode Island, about her distinguished career in chromatography.
Themro EU - Rapid Determination of Persistent Organic Pollutants (POPs) Using Accelerated Solvent Extraction
Themro EU - Rapid Determination of Fat in Meat Using Accelerated Solvent Extraction
Themro EU - Extraction of Total Petroleum Hydrocarbon Contaminants (Diesel and Waste Oil) in Soils by Accelerated Solvent Extraction
Themro EU - Extraction and Cleanup of Acrylamide in Complex Matrices Using Accelerated Solvent Extraction Followed by Liquid Chromatography Tandem Mass Spectrometry (LC–MS-MS)
Themro EU - Fast Determination of Acrylamide in Food Samples Using Accelerated Solvent Extraction Followed by Ion Chromatography with UV or MS Detection
Themro EU - Accelerated Solvent Extraction of Pesticide Residues in Food Products
Themro EU - Multi-Residue Pesticide Analysis in Herbal Products Using Accelerated Solvent Extraction with a Triple Quadrupole GC–MS-MS System
Themro EU - Rapid Determination of Polybrominated Diphenyl Ethers (PBDEs) in Biosolids and Waste Samples Using Accelerated Solvent Extraction
Bruker introduces the first software solution to encompass the complete biopharmaceutical characterization challenge, including glycoforms, impurities and modifications.
Wyatt Technology introduces the most advanced and versatile system for the separation and sizing of macromolecules and sub-micrometer particles in aqueous solutions.
GC Connections columnist, John Hinshaw, answered some of the concerns of LCGC Europe readers on switching from helium to hydrogen selected from the CHROMacademy Forum. If you want to know more about this topic please revisit the CHROMacademy webinar http://www.chromacademy.com/Translating-GC-Methods-from-Helium-to-Hydrogen-Carrier-Gas.html. An extended version of this interview will be published in the next issue of The Column.
The 6th International Symposium on the Separation and Characterization of Natural and Synthetic Macromolecules (SCM-6) has issued a call for posters.
IDEX Health & Science introduces the new Upchurch Scientific® PEEK™-Lined Stainless Steel (PLS) Tubing. The metal-free, all-PEEK fluid path withstands up to 15,000 psi, making it the ideal choice for biocompatible UHPLC applications.
Agilent (California, USA) has announced the formation of a petroleum research collaboration with the University of Houston (Texas, USA).
BAC BV (Leiden, The Netherlands) and GE Healthcare (Wisconsin, USA) have announced receipt of the ‘Collaboration of the Decade’ award at the BioProcess International Awards 2012.
Click here to view the complete E-Separation Solutions newsletter from October 18, 2012.
Novasep (Pompey, France) has announced an investment of €30 million into the construction of the world’s largest pharmaceutical chromatography plant.
Sigma Aldrich (Missouri, USA) has been recognized by the Carbon Disclosure Project (CDP) (England, UK) for its approach to the disclosure of climate change information.
Series: Increasing the Scope of your Analytical Toolbox with UltraPerformance Convergence Chromatography (UPC2) - Episode 1
Shimadzu - Analysis of PBDEs in Sediment Using GC-MS/MS
Thermo NA - Rapid Determination of Polybrominated Diphenyl Ethers (PBDEs) in Biosolids and Waste Samples Using Accelerated Solvent Extraction