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The authors explain modern UHPLC instrument design and outline simple procedures to identify causes of poor column and method performance.

The removal of azide as a potential impurity from a drug substance may be critical to its safety profile. The quantitation of thi impurity is an important control parameter. This article describes a simple and practical assay for azide using chemical derivatization and HPLC.

Part I of our yearly report, covering columns for all modes of HPLC, UHPLC, and liquid-phase separations.

Is it possible to get the same separation under isocratic and gradient conditions?

Short Courses

In this month's column, Howard Barth traces the early development of SEC

Bruker Expands Indian Operations

A discussion of different sample solvent compositions to be injected for SFC as part of injection linearity experiments

Click the title above to open the LCGC Europe April 2013 regular issue, Vol 26 No 4, in an interactive PDF format.

Click the title above to open the LCGC North America April 2013 regular issue, Vol 31 No 4, in an interactive PDF format.

The mobile version of China Chromatography Web was launched on March 7, 2013. Just input ?m.sepu.net? in your Mobile, you can acquire the large amounts of News about Chromatograph whenever and wherever.

The University of Manchester (Manchester, UK) has announced the start of the world’s biggest allergy study.

Exposure to environmental arsenic (As) is a worldwide issue, especially in locations where rice is the main calorific content in the diet.

Method validation is a concept that has been ingrained (or should have been ingrained) in the minds of most analytical chemists. Any new method that is created has to be proven reliable and provide some level of performance under well-defined conditions.

Click here to view the full Europe E-newsletter from 28 March

Waters Corporation (Massachusetts, USA) has announced the opening of a Solution Centre based within the Singapore Science Park II (Singapore).

The heart of Richard I ? King of England from 1189?1199 and nicknamed ?Richard the Lionheart? ? has been analysed by gas chromatography?mass spectrometry (GC?MS), combined with an array of other bioanalytical techniques.

Concerns have been raised throughout the scientific community about the potential effects of pharmaceuticals on the environment.

Bruker (Massachusetts, USA) has built on its 30-year history in India by opening two new centres of excellence in Mumbai and Bengaluru.

A number of retention time issues can cause problems in HPLC. Here's advice on how to handle common ones, such as retention time drift, temperature variability, problems arising from column equilibration, and difficulties validating a method.

Click here to view the complete E-Separation Solutions newsletter from March 26, 2013.

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Scientists at The Scripps Institute (California, USA) have used liquid chromatography?mass spectrometry (LC?MS) to identify a new biomarker for the diagnosis of river blindness.1

AB Sciex (Massachusetts, USA) and Leco (Michigan, USA) have formed a co-marketing partnership to provide support for researchers working in metabolomics in Europe and North America.

Click here to view the complete LCGC Europe E-Newsletter from 22 March 2013

The two triple quadrupole mass spectrometers LCMS-8040 and GCMS-TQ8030 complete Shimadzu?s UFMS series consisting of seven powerful systems. The UFMS product family provides higher sensitivity, greater excellence in data quality, increased analytical throughput and a wider range of applications.

LCGC NA - The Quantification of Clopidogrel in Human Plasma

Scientists at The Scripps Institute (California, USA) have used liquid chromatography?mass spectrometry (LC?MS) to identify a new biomarker for the diagnosis of river blindness.1