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Upcoming educational courses for chromatographers.

Immunoglobulin G (IgG)-based therapeutics are a large class of protein drugs and drug candidates that have interesting challenges in performing analytical testing, especially peptide mapping, which is necessary to fully characterize any posttranslational modifications that might occur.

Leading chromatography scientists from major pharmaceutical companies gathered recently for SFC 2009 to exchange views and discuss recent developments.

Compounds (VOCs) in Finished Drinking Water - OI Analytical Apps Note

The Pittcon Program Committee has announced that the 2010 Technical Program listing of sessions is now available on the Pittcon website.

Same-day POPs testing now feasible - FMS Apps Note

PerkinElmer has announced that pharmaceutical research and manufacturing company, Boehringer Ingelheim Pharma, is expanding its agreement with the company?s laboratory services provider.

Determining VOCs from Difficult Soil Matrices - Teledyne Tekmar Apps Notes

Succinic Acid by ANP; Simple & Cost Effective - MicroSolv Apps Note

This article looks at the benefits of using a dual-column system for the analysis of sugars and sterols.

Analysis of Carbohydrates by UltraPerformance Liquid Chromatography and Mass Spectrometry - Waters Apps Note

A High Sensitivity UPLC/MS/MS Method for the Analysis of Fluticasone Propionate in Plasma - Waters Apps Note

He and N2 Purge Gas Comparison - Teledyne Tekmar apps note

The EMS2010 meeting is an environmental mass spectrometry special interest group (EMSSIG) series event forming a part of the British Mass Spectrometry Society SIG meetings and is scheduled for 24 March 2010.

Both Chinese ginseng and Korean ginseng are similar plant species and undergo similar handling procedures when harvested and processed for sale. Despite their similarities, Korean ginseng commands a higher price than Chinese ginseng on the open market and is believed to produce different clinical effects than Chinese ginseng. Chinese researchers are now employing new techniques on the two varieties of ginseng to understand their chemical differences. HPLC/UV-based strategies for distinguishing the two types of ginseng have proven to be mostly ineffective due to lack of resolution. Using UltraPerformance liquid chromatography/orthogonal acceleration (oa)–TOF mass spectrometry and exact mass measurement, the authors developed a high-resolution method using multivariate statistical analysis for separating and identifying differences between Chinese ginseng and Korean ginseng at the molecular level.

The use of medicinal herbs as alternative treatment methods continues to grow. With this escalating use has come an increasing interest in determining the chemical compositions of these herbs in order to obtain a better understanding of their makeup and effects. In this study, Flos Chrysanthemi, a commonly used traditional Chinese medicine that has been cultivated for centuries, was analyzed to identify the main flavone compositions in one original breed of Flos Chrysanthemi (Hangbaiju) in China.

Inductively coupled plasma–mass spectrometry (ICP-MS) is a key analytical tool in many laboratories. It is used for elemental determinations across a wide range of analyses, including environmental, semiconductor, food safety, geological, chemical, petrochemical, nuclear, clinical, forensic, and research applications. Since the early publications during the development of ICP-MS, it has been apparent that one of the key limitations of the technique was the presence of molecular ions that overlap the preferred isotopes of several analytes. These molecular ions are typically called "polyatomic" ions, and are derived from combinations of the elements present in the plasma, the solvent and the sample matrix.

Inductively coupled plasma–mass spectrometry (ICP-MS) is a mature method that offers reliable measurements across almost the entire periodic table. It has been established as the key methodology for investigating elemental concentrations, which play a central role in biological, environmental, chemical, and industrial processes. ICP-MS is capable of performing multielemental analyses in a single analytical run, achieving an overall productivity of more than 50 samples/h. The method also delivers lower detection limits compared to graphite furnace atomic absorption (GFAA) or inductively coupled plasma–optical emission spectrometry (ICP-OES).

A meeting review of the 3rd International conference on Packed-column Supercritical Fluid Chromatography.

Bruker Daltonics has announced the establishment of Bruker LabMate, a life-science mass spectrometry joint venture between the company and LabMate Asia, to enhance customer support for the rapidly growing Indian market.

Metabolite profiling in drug discovery can contribute significantly at the lead optimization stage in two main application areas. The first is the identification of major metabolites, which provides medicinal chemists with information on the metabolic "soft spots." These soft spots are locations on the molecule particularly susceptible to metabolic modification, which can contribute to high pharmacokinetic clearance. This information then can be used to optimize the structure of a lead compound or chemical series to slow the rate of metabolism and therefore reduce hepatic clearance. This improves the absorption, distribution, metabolism, and excretion (ADME) properties of the compound, such as bioavailability, exposure (as measured by area under the curve), and half-life. Through iterative optimization of the structure and timely generation of metabolism data following each structural modification, pharmacokinetic properties can be improved while maintaining activity against the therapeutic target.

Fat soluble vitamins were analyzed with SFC-UV-MS. With SFC MS, 7 of the 9 vitamins in the suspension were identified. Low concentration Vitamin A was successfully quantified by SFC UV.

Analysis of CMC materials can be easily achieved by utilizing PL aquagel-OH columns and the PL-GPC 50 Plus with RI and viscometry detection.

Sugar and Sterol Analysis in Human Body Fluids Fokje S.M. Zijlstra, Leo A.J. Kluijtman and Mark H.P.M. van Lieshout "This is What I've Been Looking For" - The Quest For The Ideal Column Connector In this case study, Frank van Geel spoke to Theo Jelink from AkzoNobel about his findings after the Melfit One connecting device from NLISIS News More fuel for thought, ageing bananas, a society name change and an asset purchase agreement are featured this week. Incognito Are You Optimizing Your Solid-Phase Extraction: Part 2 Incognito dedicates Part 2 of his series on solid-phase extraction to answering the questions posed in Part 1 regarding the SPE of propranolol from plasma exract Events

Membrane Protein Quaternary Structure - Wyatt apps note

Carboxymethyl cellulose (CMC) is a derivative of cellulose with carboxymethyl groups (-CH2COOH) attached at some of the hydroxyl groups that typically make up the cellulose backbone.