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The quantification of candidate pharmaceuticals and/or their metabolites in biological fluids plays a key role in drug discovery.

Incognito answers Part 1's remaining questions to help you achieve optimized solid-phase extraction.

The combination of small particle size and narrow particle size distribution, coupled with the significantly shorter diffusion path provided by the Kinetex™ core-shell particle, results in a material that yields significantly increased column efficiencies and chromatographic resolution. This is a benefit for separation scientists looking to achieve better performance, especially with complex separations containing many compounds and very closely eluting compounds so that accurate identification and quantitation can be achieved.

The answer to the following question was supplied by LCG Europe's "GC Connections" columnist John Hinshaw.

Agilent Technologies has purchased MassCode Tag technology from Eurofins MWG Operon, a division of Eurofins. According to the company, the technology will allow them to develop new research products for pathogen identification, leveraging its strength in polymerase chain reaction (PCR) and mass spectroscopy.

Click here to view the November Data Handling/Software newsletter in its entirety.

This article discusses the business benefits of interfacing laboratory applications together to eliminate paper and streamline working practices.

Participants in this Technology Forum are Linda Doherty of Agilent Technologies, Tom Jupille of LC Resources, and Barry Coope of Thermo Fisher Scientific.

This article looks at a novel approach to enhance the sensitivity of radioactivity flow detection.

The new Shimadzu fluorescence detectors enhance the excellent performance of the prominence HPLC series. The detectors support a wide range of applications from routine to high-performance and ultra-fast analysis

The 2010 – 2012 Thermo Scientific catalog showcases the broadest collection of chromatography columns and consumables. Over 500 new pages of high quality tools ensure unrivalled choice for all separation needs.

Agilent Technologies announced that together with the Shanghai Institute of Biological Sciences (SIBS), the company has opened the joint SIBS-Agilent Centre for Systems Biology in Shanghai, China.

Does Optimization in the Manufacturing Process of An Established CSP Make A Difference in Chiral Separations? Ted Szczerba and Andrew Geyer Meeting Review: The 14th Desty Memorial Lecture for Innovation in Separation Science Peter Myers News Fishy aftertastes, quantifying human proteins, improving F1 performance and networking topics at Pittcon are featured in this issue. Market Trends and Analysis Market Profile: CE-based DNA Sequencers Glenn Cudiamat Incognito Are You Optimizing Your Solid-Phase Extraction? (Part 3) Events and Staff

LC–MS method for analysis of vitamin D metabolites in serum.

Exeter Analytical has announced that it recently installed one of the company?s elemental analysers at contract analytical service laboratory - Butterworth Laboratory, in Teddington, UK.

Temperature is shown to be an effective tool for changing selectivity in complex mixtures separated using supercritical fluid chromatography (SFC).

News from the chromatography world as of November 2009.

Upcoming educational courses for chromatographers.

Upcoming events in the chromatography community as of November 2009.

Pittcon has announced who will be receiving ten prestigious awards during the convention between 28 February and 5 March 2010. This year?s awardees represent diverse scientific disciplines including bioanalytical science, biomedical, chromatography, electrochemistry, mass spectrometry and separations science.

The new technologies for fast LC, UHPLC and rapid resolution LC provide the researcher with unrivalled resolution and peak definition along with potentially much shorter chromatography run times.

Using ACQUITY UPLC® and Xevo™ QTof MS for the semi-targeted screening of more than 150 veterinary drug residues and metabolites including avermectins, benzimidazoles, β-agonists, β-lactams, corticosteroids, macrolides, nitroimidazoles, quinolones, sulfonamides, tetracyclines and other veterinary medicinal products.

The analysis of pesticides in environmental samples is an important part of monitoring the condition of the environment. This note describes the separation of trichlorobenzene from a sample of sardines.

Guidelines for companies placing product profiles within the LCGC Europe E-Newsletters.

Rapid screening of veterinary drug residues with integrated workflow solution - Waters Apps Note

Observations in the Analyses of Poly(ethylene glycol) Oligomers and Tween 80® Using SFC-MS - Thar Apps Note

Hichrom, UK based HPLC column manufacturer, has announced the acquisition of the Ultrasphere HPLC column consumable product line from Beckman Coulter, a US based manufacturer of biomedical testing instrument systems, tests and supplies.

Click here to view the November HPLC newsletter in its entirety.