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Q&A with Kory Kelly of Phenomenex; Nicholas H. Snow of Seton Hall University; and William Goodman and Adam Patkin of PerkinElmer, Inc.

Chiral Technologies Europe has announced that its new chiral separations laboratory, commissioned earlier this year, is now operational and is separating compounds for biotechnology and pharmaceutical companies across Europe.

Dionex Corporation (Sunnyvale, California) will be hosting a series of free seminars on liquid chromatography throughout the United States and Canada from September 9?October 29, 2009.

In today's economy, science driven organizations are under increasing pressure from customers, shareholders and competitors.

Determination of Anions in Bayer Liquor using IC - Dionex lcgc apps note

Introducing TharSFC X5?: a Parallel SFC System for Fast Method Development and Optimization - Thar apps note

They say it takes several years for an awards program to really get off the ground and start amassing a history, establishing a place for itself in the industry. If this is true, then I believe we can safely say that this year, the LCGC Pittcon Awards have officially arrived.

An Investigation of the Impact of Common Experimental Parameters on Signal Intensity in SFC ESI MS - Thar apps note

The answer to the following question was provided by Kevin Altria, LCGC Europe's "CE Currents" column editor.

IC Separation of Tryptophan and Methionine Oxidized Peptides - Dionex Apps NOte

The autumn leg of PerkinElmer?s 2009 European ?For the Better? Tour will soon get underway. At this series of seminars, scientists, industry leaders and the company?s specialists will share their applications expertise and demonstrate how the company?s solutions can be used in sectors as diverse as environmental analysis, food safety, polymers and chemicals.

Comprehensive multidimensional gas chromatography time-of-flight mass spectrometry has emerged as an excellent instrumental option for the characterization of small metabolite profiles.

Development and production of biopharmaceuticals is a growing segment of the pharmaceutical industry. The development of vaccines is only one - but as a result of the current H1N1 flu hysteria it is the most striking - segment of this emerging field. Recombinant proteins, ranging from insulin products to therapeutic antibodies, represent another important group of biopharmaceuticals. With the introduction of the first so-called biosimilars in Europe the demand for highly efficient analysis methods is further increasing. Newly developed stationary phases for the typical modes of biochromatography of native proteins such as SEC or IEC open up new opportunities for increasing throughput in the bioanalytical lab.

Corn stover is the above-ground portion of the plant minus the kernels and it accounts for a large percentage of the global supply of lignocelluosic biomass available as feedstock for fermentation systems used for biofuel production.

The term ionic liquid refers to organic salts with relatively low melting points (below 100 °C) that usually consist of an organic cation or anion and a counterion, in either organic or inorganic form.

The QuEChERS method for pesticide analysis was first introduced by USDA scientists in 2003.1 The EN method 15662:2007 is a European variation to the QuEChERS method.2,3

The analysis of the molar mass distribution of polyethylene and polypropylene resins by GPC/SEC has always been considered a demanding task because of the requirement of high temperature operation for dissolution and complex hardware design, which often results in high maintenance cost, in particular related to the autosampler/injector and detector units, and in other problematic and consuming tasks such as solvent handling added to column fragility, sample degradation or detector sensitivity–stability.

To guide the development of aggregate free protein formulations, there is an urgent need for complementary methods that allow a sensitive detection, characterization and quantification of different types of protein aggregates.

Over-expression of recombinant proteins is commonly used for the production of protein reagents in industry and academia. Problems often occur relating to the stress put on the cells to deal with this huge increase in synthesis. Cellular proteins that are part of the protein synthesis machinery are often up-regulated under such conditions. Large quantities of the recombinant protein can be bound to these cellular proteins, making purification difficult.

A critical part of research and quality control analysis of proteins involves verifying the primary and secondary structure of a protein. Peptide mapping is the main technique used to determine the structure of a protein as well as identify any post-translational modifications.

Oxidation of amino acid residues can alter a protein's biological activity, half-life and immunogenicity. Peptide maps can be used to detect oxidized peptide fragments. Peptides are commonly separated by RP-HPLC; however, hydrophobic interaction chromatography (HIC) is an alternative technique offering different selectivity.

Recent advances in ultrafast liquid chromatography

As a result of their high toxicity and carcinogenicity, aflatoxins are of major concern for food producers, the food processing industry and consumers. Most countries have legislation setting maximum permissible limits for aflatoxins, which are in the low micrograms per kilogram for food matrices.

The analytical challenge treated in the present work consists in determining sub-ppb concentrations of low-molecular-weight amines in the presence of strongly retained cationic drugs by using ion chromatography (IC) with upstream in-line coupled-column matrix elimination (CCME).

This study uses the challenging analysis of a complex, multi-organ peptide digest of Caenorhabditis elegans (C. elegans) to compare the performance of a novel linear ion trap mass spectrometer and a quadrupole time-of-flight (Q-TOF) mass spectrometer.

Polyacrylonitrile (PAN) is an important component of many synthetic products such as heavy-duty fibres, synthetic ropes, flame resistant plastics and clothing.

Recently a newly developed Kinetex 2.6 µm core-shell chromatographic particle has been commercialized that offers the performance benefits of sub-2 µm fully-porous particles but at substantially lower operating pressures.

In this application, we demonstrate the use of supported liquid extraction (SLE) for the extraction of beta blockers and NSAIDS from plasma compared with traditional liquid–liquid extraction. SLE was demonstrated to yield consistent LOQs using lower sample volumes.