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This article introduces the advantages of accurate mass high-resolution mass spectrometry LC–MS (HRMS) coupled to the dried blood spot (DBS) technique for fast PK applications in a discovery environment. Compared with the established norm of plasma bioanalysis using triple quadrupoles, HRMS coupled to DBS is a viable alternative. The benefit is access to critical new information (HRMS bioanalysis) and significantly less stress on the animal (DBS), both factors that potentially improve the quality of early PK data.

The threat to human health posed by the recent oil spill has created a pressing need for high-throughput seafood analysis to ensure that it does not contain dangerous levels of polycyclic aromatic hydrocarbons (PAHs) and to allow the earliest possible reopening of the fisheries. Adapting QuEChERS sample preparation technology to this application, combined with the use of preconfigured PAH gas chromatography–mass spectrometry analysis systems, can provide the ability to process in a timely manner the enormous number of samples that will be generated by the ongoing testing program.

The development of a phosphorylation probability scoring tool in an automated data search engine resolves ambiguity in site localization when compared to manual methods.

A high-throughput LC–MS method using core-shell UHPLC columns to screen for a panel of 11 drugs of abuse (expanded SAMHSA) was developed. The corresponding SPE method allowed the reproducible separation and quantitation of these 11 components in less than 2 min. This method demonstrates the power of new-generation HPLC media as well as some of the factors one must consider when developing such methods for LC–MS analysis.

The analysis of urine for drugs of abuse via chromatographic methods is commonplace but can be complicated by high matrix effects and frequent coelution. Novel time-of-flight mass spectrometry in combination with sophisticated deconvolution software was tested and found to provide increased confidence in results due to the high sensitivity and quality of spectra achieved.

The LCGC Awards have now been in existence since 2008, and with several years of award winners now active in the chromatography community, it is fair to say that we now have a reasonable track record and body of work to review in measuring the impact these awards have had, both on the industry and on the winners themselves.

Click the title above to open the LCGC North America October 2010 regular issue, Vol 28 No 10, in an interactive PDF format.

Click the title above to open the October 2010 issue of Current Trends in Mass Spectrometry, Volume 8, Number 4, in an interactive PDF format.

Waters Corporation

Agilent Technologies has announced that Maquet of Ardon, France, has purchased the company?s OpenLAB ELN electronic lab notebook bundled with Surety's AbsoluteProof third-party, digital timestamping service.

An affiliate of New Mountain Capital announced the completion of its acquisition of Mallinckrodt Baker from Covidien for approximately $280 million.

Thermo Fisher Scientific is sponsoring the 15th Desty Memorial Lecture for Innovation in Separation Science, which will take place at the Royal Institution of Great Britain on the 6th October 2010.

Knauer Application note

Antec application note

Waters Xevo TQ-S is designed for the most demanding quantitative UPLC/MS/MS applications. Using direct injection on Xevo TQ-S removes sample preparation and enables a simple, high-throughput analysis of pesticides in drinking water.

The second Kuwait Laboratory Technology Conference and Exhibition will be held 30 November?1 December 2010.

CTE acquired exclusive manufacturing and marketing rights for novel Cinchona alkaloid-based zwitterion-exchange type chiral stationary phases (CSPs), invented and developed by researchers at the University of Vienna.

Agilent Technologies has announced that a group of researchers from the University of California, Davis, USA, has found that human breast milk contains an unexpected abundance of sugars that coats the lining of infants? intestines, protecting it from noxious bacteria.

The knowledge of the metabolic pathways and the bio-transformation of new drugs are crucial for elucidation of degradation routes of the new active compounds, especially in the area of possible toxicity.

Polymer Standards Service - UGPC? - New Dimensions for GPC/SEC

Waters Corporation - Bioanalysis, matrix effects

Waters - Detection of Pesticides in Drinking Water Using Direct Injection UPLC/MS/MS

Waters (Sylvie) - Analysis of Veterinary Drugs Using ACQUITY UPLC CSH Columns

Thermo Fisher Scientific has extended its reach across Central Europe by making Vialis AG the latest member of its Informatics Global Partner Alliance.

Watch the Video and Download the Notes! Ron Majors leads the way to getting more speed and resolution from any HPLC, using the power of Agilent Poroshell 120 columns to transfer your existing method.

To support what the company describes as a growing customer base in South East Asia in the fields of automated sample preparation for GC-MS and LC-MS, GERSTEL has founded a subsidiary in Singapore.

Gilson introduces a new personal bench top purification system. The PLC 2020 Purification System is ideally suited for low throughput; high pressure purification needs and is intended to support an individual or small group of chemists.

Participants in this Technology Forum are from Agilent Technologies, Thermo Fisher Scientific, and Waters Corp.