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By now, a reader would have to be living in a log cabin without electricity to be unaware of the acetonitrile shortage currently gripping the chromatography market. The causes, effects, and possible solutions have been documented thoroughly in the pages of LCGC and other industry journals, to the point where the basic facts are common knowledge: the shortage began with (among other factors) the depression of the automobile industry and the consequent reduced production levels. With ACN being a byproduct of this process, its production was reduced as well.

New and better software solutions are being created every day in the marketplace, leading to some exciting breakthroughs that promise to make labs and businesses in general more productive.

A mature technique that is finding new and innovative applications every day, capillary electrophoresis has come to the forefront in much of the recent literature, with the feature article of the August issue of LCGC being dedicated to this technique. We expect that interest in CE will only continue to grow in the future.

From environmental research to petroleum research to testing blood for doping agents, GC remains a workhorse in the field of chromatography. And though other techniques are challenging GC and seeking to dethrone it, none have been completely successful to this point, as GC promises to remain relevant for years to come.

With an ACN shortage gripping the industry, sample prep has become more critical than ever to the productivity of the modern separations lab. Here our experts explore this topic.

Technology Forum: SFC

With the ACN shortage showing few signs of letting up in the near future, ACN-free methods such as SFC are receiving increased attention and interest. Here our experts discuss this technique.

HPLC and in particular, UHPLC, continue to grow in popularity in the world of separation science, with the UHPLC market predicted to grow 19% by 2012, even in these difficult economic times ("Global Assessment Report," SDi, Inc., 2008).

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This article describes a new workflow technology in a chromatography data system (CDS) software program. Using this workflow streamlines workflows in chromatography laboratories, enabling users to set-up sequences, process data, and report results in the shortest possible time. This typically speeds up the generation of results, thus, more than matching typical throughput increases found when using UHPLC technology.

Varian, Inc. has published an application note entitled Light Scattering Analysis of BSA with ProSEC 300S Columns. ProSEC 300S is a silica-based packing with a surface modified for compatibility with proteins, ensuring that true size exclusion is obtained with minimal unwanted interaction affects.

Researchers from Huazhong University of Science and Technology (Wuhan, China) and the National University of Singapore (Singapore) developed a liquid-phase microextraction method based on solvent-bar microextraction.

Eksigent Technologies has announced that it will be stepping up its manufacturing capabilities by 40%, as well as expanding the company?s servicing capabilities, to meet demand for its HPLC products.

Simultaneous Extraction and Rapid Analysis by LC–MS–MS of Melamine and Cyanuric Acid Jeremy S. Bierman, Philip J. Koerner and Michael V. Campognone 'ILICs' Are Not Everything In Polar Retention A reader response to Incognito's article featured in the May issue of The Column On-line SPE-LC for The Determination of Catecholamines in Urine with Fluorescence Detection Silvia Marten News Cannabis as a carcinogen, aid for disaster victims, an anti-doping research grant and the proteomics market are featured in this issue Incognito Quality by Design - Or Death by Statistics? Incognito considers the usefulness and scope of the 'Quality by Design' approach to HPLC method development through a question and answer format. Events

Chromatographers with an interest in radio-HPLC flow-through detection are invited to book their place at LabLogic Systems' demonstration tour for the Model 5 Beta-RAM, which the company says has toured the UK, Switzerland and Holland and will also appear in France, Germany, Denmark and Sweden.

Wyatt Technology (Santa Barbara, California) recently received awards from The Scientist magazine and the South Coast Business and Technology Awards.