Analytical Theory

Mass spectrometry (MS) can be effective in identifying unknown compounds, though this can be complicated if spectra is outside of known databases. Researchers aimed to test MS databases using electron–ionization (EI)–MS.

When analyzing samples using liquid chromatography–high-resolution mass spectrometry, there are various ways the processes can be improved. Researchers created new methods for prioritizing these strategies.

Physics-informed neural networks were tested for their capabilities in predicting concentration profiles in gradient liquid chromatography.

Henan University scientists recently combined capillary electrophoresis (CE) and magnetic solid-phase extraction (MSPE) to isolate flavonoid compounds from Lonicera japonica Thunb leaves.

During EAS 2024, Jay Sheffer, a Product Specialist at Metrohm USA, discussed how combustion ion chromatography (CIC) can help address PFAS’ impact on the environment.

A scientist from Agilent Technologies spoke about research analyzing extractables and leachables identified in rubber gasket extracts.

University of Bonn scientists monitored how column properties can affect the dynamics between characteristic and elution temperatures in gas chromatography (GC).

Dan Wispinski, the Standard Methods Development Manager for VUV Analytics, held a lecture at the Gulf Coast Convention in Galveston, Texas, which focused on the adoption of gas chromatography–vacuum ultraviolet spectroscopy (GC-VUV) technology.

A recent study published in the Journal of American Society of Mass Spectrometry introduced a new method for characterizing nonpolar lipids (1).

Pop quiz—can you define resolution? Would you be surprised at the number of correct answers? Which one is the best for chromatographers? In this LCGC Blog, we look at the various ways resolution can be interpreted scientifically.

Understanding the relationship between a number of variables and analysis time, and their effects on other choices made during method development, is helpful for developing methods that are both effective and time-efficient.

As part of the upcoming Recent Advances in Gas Chromatography meeting, Paul O'Nion of RSSL will provide his perspective on different elements in the periodic table.

An examination of how greening analytical methods is directly connected to greening the sample preparation step

Pop quiz – can you define resolution? Would you be surprised at the number of correct answers? Which one is the best for chromatographers? In this LCGC Blog, we look at the various ways resolution can be interpreted scientifically.

A recent study reveals that pesticide residues in herbs have a low transfer rate to herbal infusions, ensuring safer consumption of these products. The validated analytical method used in the study provides valuable insights into the levels of pesticide residues in herbs and their limited presence in the resulting infusions.

In his plenary lecture at HPLC 2023, Michal Holčapek presented his team's findings on how chromatography can help scientists record the human lipodome and better our understanding of diseases.

Metal organic frameworks (MOFs) and ionic liquids (ILs) combine to form a powerful gas chromatography stationary phase, enabling improved separation properties and expanded application possibilities. This innovative system offers enhanced separation capabilities and paves the way for advancements in gas chromatography analysis.

A new way to control ion transports in microfluidic systems has the potential to improve the technology and expand applications.

In this LCGC blog, we reflect on the movement to make analytical chemistry more environmentally friendly, and how to potentially better those efforts for the industry's future.

Developing a short list of likely causes of retention-time problems in reversed-phase LC makes troubleshooting easier.

A kinetic plot is a powerful tool, but how do you construct one—from either experimental data or data from other sources? We explain.

When applying Golay’s equation for height equivalent of a theoretical plate (HETP) to capillary GC, you should ask three key questions.

Barry L. Karger and James P. Grinias are the winners of the 15th annual LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards, respectively, for 2022. Here, we review their achievements.

Kinetic plots can help us understand how different combinations of parameters will perform in relation the time needed to acquire a particular column efficiency—and thus resolution.

We are all familiar with Golay’s equation relating to height equivalent to a theoretical plate (HETP) in GC. But do we understand it correctly?