Multidimensional GC

Exploring the use of GCxGC-FID as a technique for qualitative and quantitative analysis of perfumes

The GC×GC-7 symposium ran concurrently with this year?s ISCC in Riva del Garda, Italy. Speaking with The Column, Philip Marriott of the Australian Centre for Research on Separation Science, RMIT, Melbourne, Australia, said it ?offered the most comprehensive and thorough GCxGC programme yet assembled.?

Comprehensive two dimensional gas chromatography–mass spectrometry is a powerful method to identify target analytes in complex matrices. An example is shown of identification of pesticides in citrus oil.

Coelutions using one dimensional chromatography are often observed in flavour and fragrance analysis.

The misuse of androgenic anabolic steroids in sports was banned in 1976 by the International Olympic Committee and global sports community. The illegal use of anabolic steroids has reached disturbing levels worldwide. This worldwide problem is fueled partially by an ever-increasing demand for better athletic performance. The World Anti-Doping Agency has formulated strict guidelines for minimum allowable concentrations of exogenous anabolic steroids and their metabolites. The standard test methods for doping control are analyzed in urine samples with trimethyl-silyl derivatization. Urine is a complex and difficult biological matrix. This research shows the advantages of using comprehensive two-dimensional gas chromatography–time-of-flight-mass spectrometry (GCÃ-GC–TOF-MS) and illustrates the capability of GCÃ-GC-TOF-MS to be an effective instrumental option for antidoping control screening.

In this article, the combination of SPME with GCxGC and GCxGC–TOF-MS is discussed using mixtures of solvents as example analytes

Retention Times of 209 PCB Congeners Using GCxGC-TOFMS - LECO apps note

Demonstrating the suitability of a new wax stationary phase for GCxGC analysis of essential oils

Design of a FID/MS Splitting for MS Detection in The First and Second Dimension of a Multidimensional GC–MS System

Why is thermal modulation more widely discussed than flow modulation in comprehensive multidimensional gas chromatography?

This article discusses the unique properties of ILs and their potential impact as GC stationary phases.

Smokeless tobacco can contain thousands of analytes, making it an extremely difficult matrix for identification of pesticide residues.

Guest columnists explore how ionic liquids can be tweaked to mimic the popular stationary phases of today.

Non-Derivatized Drugs in Urine by Automated SPME GCxGC-TOFMS-LECO Application Note

Polybrominated diphenyl ethers (PBDE) are persistent environmental contaminants that are being extensively studied by environmental researchers worldwide. Their potential for toxicological impacts on humans and wildlife has made them a focal point of regulatory agencies. Their widespread use as flame retardants in electronics, household furniture, and many other building materials has lead to a need for analysis of many different sample matrices, including very complex environmental samples.

The interpretation of comprehensive two-dimensional gas chromatography (GCÃ-GC) based on the modulation ratio (MR) concept encompasses method implementation, ideas on quantitative measurement and how modulation phase affects GCÃ-GC.

We spoke to Marco Koenen and Ed Ledford of Zoex about the rising popularity of multidimenional gas chromatography.

Differential flow modulation is an inexpensive way to perform GCÃ-GC separations which has been attracting growing attention recently. Differential flow modulation uses high carrier gas flow rates in the second dimension column so it is widely thought that this rules out direct coupling with mass spectrometry. However direct coupled GCÃ-GC-QPMS using differential flow modulation is reported here for the first time using an unmodified mass spectrometer comprising a dual inlet turbomolecular pump and fast scanning quadrupole mass analyser. The suitability of the approach for characterization of essential oils is demonstrated.

Researchers Philip Marriott from the RMIT University (Melbourne, Australia), Warawut Tiyapongpattana, and Prapin Wilairat from the Mahidol University (Bangkok, Thailand) have developed a 2D GC with FID method for determining the composition of biofuels that extends to the C4-C24 esters. They reasoned that a 2D separation, based first on boiling point then on polarity, would provide better resolution of the components.

The authors present results that suggest that high-throughput, high-coverage profiling capabilities, such as those afforded by GCxGC-TOF-MS, can impact the development of personalized medicine.

Gas chromatography and comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC–TOFMS and GCxGC–TOFMS) were utilized to develop trace-level calibration curves in brewed green tea spiked with organochlorine and organophosphorus pesticide standards. A sensitive and robust calibration curve was developed from 10 to 500 parts per trillion (ppt), which allowed quantitative results to be determined for organochlorine–organophosphorus pesticides in brewed green tea. Exceptional limits of detection were achieved by GC–TOFMS and GCxGC–TOFMS at or below 10 ppt (solution concentration) for all but one of the pesticides. Stir bar sorption extraction (SBSE) was utilized to isolate the pesticide components from brewed green tea samples prior to analysis by GC–TOFMS and GCxGC–TOFMS. Different types of green tea were analyzed qualitatively by SBSE and GC–TOFMS with subsequent quantification for organochlorine–organophosphorus..