Multidimensional GC

Comprehensive GCxGC was employed for the separation of ICH and USP 1, 2, and 3 pharmaceutical solvents. The significantly improved peak capacity in GCxGC allows a single method for any combination of solvents and mitigates interference due to impurities in the solvents, diluents, analyte matrices, and from column or septum bleed, through the increased separation space.

The increased resolving power provided by comprehensive two-dimensional gas chromatography (GCxGC) extends the chromatographer's ability to rapidly detect and measure smaller components in complex mixtures beyond that which was possible previously, allowing for the identification of hazardous components in complex mixtures such as foodstuffs or emergency response samples. In target analysis, the increased numbers of peaks resulting from the sample matrix can be largely ignored during the review of data. However, when the nature of the analyte of interest is not entirely known, analysis of the samples might require screening through the entire peak table for compounds with specific chemical characteristics. For example, in the analysis of foodstuffs for pesticides (1,2), GCxGC coupled with a time-of-flight mass spectrometry (GCxGC–TOF-MS) can provide low detection limits for multiple analytes in these complex samples. Yet the question remains as to whether other toxic compounds, not included in the..

It may be somewhat audacious to claim that some methods in GCÃ-GC can be called non-classical - the technique has only been around for about 15 years and one might argue that this is not long enough to establish a suite of classical methods.

October 2006. This brief review introduces the GCxGC technique and its advantages, hich primarily lie in the area of ncreased separation power for volatile chemical analysis.

Tincuta Veriotti, LECO Corporation

The latest newcomer to the collection of GC techniques, GCXGC, is examined in this instalment. Although this technique is capable of delivering more GC information in a shorter time than other methods, its technical complexity has slowed down widespread acceptance. John Hinshaw explains...

John Hinshaw discusses advances in the field of two-dimensional gas chromatography.