Multidimensional GC

GCxGC started out as a specialized technique. However, the technique and it's instrumentation have evolved significantly in the past decade. Does it make sense to use GCxGC in routine analysis?

Latest newsletter from June 12 2014.

Newsletter from June 5 2014.

The latest newsletter from March 20.

Frank L. Dorman of Penn State University talks about the evolution of GCxGC and the key advantages and disadvantages of the technique, including why fear of its complexity gets in the way of its broader use.

The latest newsletter from March 13.

Click here to view the full European E-newsletter from March13 2014.

Here, a method to characterize edible oils and edible oil mixtures through fingerprinting and the isolation of individual analyte differences is reported. Aroma and flavor analytes in extra virgin olive, olive, peanut, grapeseed, and vegetable oils were sampled with headspace solid-phase microextraction (HS-SPME).

Pulsed-flow-modulated comprehensive two-dimensional gas chromatography with flame ionisation detection was used to separate and identify all common sulphur compounds found in natural gas.

LECO Corporation

A method able to quantitate odorants at levels as low as 100 ppb (v/v)

A carefully chosen analytical technique can enhance the inherent advantages of passive sampling of watercourses over more traditional "grab" or "spot" sampling.

Invented by J. Phillips in 1989, comprehensive GCXGC has strong chromatographic resolving power; from its original petrochemical applications it has been extended to many others. However, coelutions with matrix peaks are often observed and a higher separation power is required.

One fast, simple QuEChERS extraction for a broad range of pesticides.

An excerpt from LCGC's e-learning tutorial on multidimensional GC at CHROMacademy.com.

Achieving efficient analyte transfer between columns is critical to gaining the benefits of multidimensional GC.

An excerpt from LCGC's e-learning tutorial on HPLC on multidimensional GC at Chromacademy.com.

Comprehensive GCÃ-GC(qMS) provides a maximum chromatographic separation power in gas chromatography (GC). Combining it with the highly selective negative chemical ionization (NCI) mode gives highest sensitivity for electrophilic molecules like trichloroanisole and tribromoanisole.

The International Symposium on Capillary Chromatography (ISCC) has established its reputation as forum for microcolumn separation techniques and, over the years, the most important developments in capillary gas chromatography, microcolumn liquid chromatography and electromigration techniques have been presented in this symposium series.

GCxGC-TOFMS provided a comprehensive analysis of tobacco smoke. Individual smoke constituents across several target compound classes were extracted, chromatographically resolved, then identified and quantified with mass spectral detection.

Analysis of natural compounds is becoming increasingly important. One thriving area is the evaluation and application of environmental biopolymers, such as humic substances (HSs) in various applications, including medicine, industry, agriculture and environmental protection.

Describes a novel approach for the enantioselective separation of spearmint oil incorporating a fluidic modulation system.

SFC–GCxGC is shown to be useful in fossil fuel analysis. Practical examples for the analysis of complex matrices are described.

Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.

Slides to accompany the vidcast interview from Pittcon 2011 with Luigi Mondello, Professor, Analytical Chemistry, School of Pharmacy, University of Messina