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GPC/SEC Tips & Tricks: Improving the Reliability of GPC/SEC Light-Scattering and Viscometry Results

October 17, 2011

The Column

The Column, The Column-10-17-2011, Volume 7, Issue 19

On-line light scattering and viscometer detectors increase the information depth of GPC/SEC data and allow absolute molar masses and structures to be measured.

On-line light scattering and viscometer detectors increase the information depth of GPC/SEC data and allow absolute molar masses and structures to be measured. However, even a set-up with advanced instrumentation is not parameter free and the inter-lab comparison of results is often sobering. Sometimes even the comparison of inter-lab results or the reproducibility is not acceptable. In most instances the reason for these deviations can be related to a wrong determination of the slice concentration. In contrast to conventional GPC/SEC, hyphenation with molar mass sensitive detection requires the precise and accurate knowledge of the mass in every chromatographic slice

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