|Articles|May 1, 2001

LCGC North America

  • LCGC North America-05-01-2001
  • Volume 19
  • Issue 5

Microdialysis Sampling - Challenges and New Frontiers

This installment of "Sample Prep Perspectives" discusses microdialysis sampling and the opportunities and challenges it presents. The guest authors look at microdialysis theory and equipment and describe potential applications...


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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.