New Approaches to Protein Precipitation: Effective Phospholipid Removal Improves Results
In clinical and pharmaceutical testing, analkyses of drug compounds and their metabolites are often performed in complex biological matrices, such as plasma and whole blood.
In clinical and pharmaceutical testing, analkyses of drug compounds and their metabolites are often performed in complex biological matrices, such as plasma and whole blood. Endogenous components in plasma samples can negatively impact the accuracy and precision of analyses. New techniques to remove phospholipids from plasma samples have recently been developed to eliminate ion suppression effects that can occur from these compounds. Method development and additional steps are not required, making this a simple, fast and effective way of removing signal suppression effects.
Analyzing Effects of Adverse Cardiovascular Events on Chronic Kidney Disease with HPLC
March 13th 2025Researchers investigated the potential association between plasma apolipoprotein M (APOM) levels and the risk of adverse cardiovascular outcomes in individuals with chronic kidney disease (CKD). Plasma sphingosine-1-phosphate (S1P) levels were measured by high performance liquid chromatography (HPLC).
New Study Investigates Optimizing Extra-Column Band Broadening in Micro-flow Capillary LC
March 12th 2025Shimadzu Corporation and Vrije Universiteit Brussel researchers recently investigated how extra-column band broadening (ECBB) can be optimized in micro-flow capillary liquid chromatography.
