New Approaches to Protein Precipitation: Effective Phospholipid Removal Improves Results
In clinical and pharmaceutical testing, analkyses of drug compounds and their metabolites are often performed in complex biological matrices, such as plasma and whole blood.
In clinical and pharmaceutical testing, analkyses of drug compounds and their metabolites are often performed in complex biological matrices, such as plasma and whole blood. Endogenous components in plasma samples can negatively impact the accuracy and precision of analyses. New techniques to remove phospholipids from plasma samples have recently been developed to eliminate ion suppression effects that can occur from these compounds. Method development and additional steps are not required, making this a simple, fast and effective way of removing signal suppression effects.
High-Throughput 4D TIMS Method Accelerates Lipidomics Analysis
April 25th 2024Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.
