From the Publisher
In a market as dynamic and fast-paced as ours, it should come as no surprise that in the months since I last addressed our readers in this space, a great deal has taken place in the world at large and in the field of separation science in particular.
In a market as dynamic and fast-paced as ours, it should come as no surprise that in the months since I last addressed our readers in this space, a great deal has taken place in the world at large and in the field of separation science in particular. Many issues that dominated the headlines just a few short months ago have now evolved and given way to new issues that may require new solutions.
Michael J. Tessalone
At LCGC, we continue to believe as we always have, that the notes contained in The Application Notebook are something of a microcosm of the marketplace, reflecting the ongoing and evolving issues that face chromatographers every day, and this edition is no exception. With the biotech industry continuing to make strides, you will see numerous application notes across this field, including many on biopharmaceuticals. With concerns over the long-term price of acetonitrile now beginning to replace supply considerations in many minds, you will find notes that offer new and innovative ways to conserve solvent. With food safety continuing to be a major concern in the U.S. and world markets, more stringent testing is being implemented, and here you will find corresponding application notes with new and better food testing methods, created in large part to meet this challenge.
In short, if you are experiencing an issue in your lab or business, chances are you will find it being addressed in one of the application notes contained in this issue. And if by some chance you do not, then please feel free to let us know. We rely on your feedback to help us shape future content and projects down the road, so do not hesitate to contact myself or any of our staff at the listings found in the masthead.
Enjoy the issue.
Michael J. Tessalone
Science Group Publisher
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Investigating Plastic Contamination in Olive Oil with GC–MS/MS
January 17th 2025The objective of this study was to investigate contamination by 32 plasticizers in olive oil throughout its production and packaging process. Separation and detection were carried out by gas chromatography tandem mass spectrometry (GC–MS/MS), without the need for pre-concentration steps.
Top Execs from Agilent, Waters, and Bruker Take the Stage at J.P. Morgan Healthcare Conference
January 16th 2025The 43rd Annual Healthcare J.P. Morgan Healthcare Conference kicked off in San Francisco earlier this week. Here’s what top executives from Agilent, Bruker, and Waters, discussed during the event.
