"Sigma" Approaches to Maintain Quality and Reduce Variations when Performing Chromatography Analysis

Sigma approaches are used to reduce variations and improve quality when performing chromatographic procedures. The terminology of this approach is introduced, together with illustrative examples and suggestions. Although this “Sigma” methodology was originally developed for industrial use or in factory environments, it is increasingly being used in analytical laboratories — most notably in pharmaceutical companies. An earlier article in The Column described how to achieve reductions in wastes (“Lean”) that can occur in chromatographic operations.

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