"Sigma" Approaches to Maintain Quality and Reduce Variations when Performing Chromatography Analysis
Sigma approaches are used to reduce variations and improve quality when performing chromatographic procedures. The terminology of this approach is introduced, together with illustrative examples and suggestions.
Sigma approaches are used to reduce variations and improve quality when performing chromatographic procedures. The terminology of this approach is introduced, together with illustrative examples and suggestions. Although this “Sigma” methodology was originally developed for industrial use or in factory environments, it is increasingly being used in analytical laboratories — most notably in pharmaceutical companies. An earlier article in The Column described how to achieve reductions in wastes (“Lean”) that can occur in chromatographic operations.
Identifying and Rectifying the Misuse of Retention Indices in GC
December 10th 2024LCGC International spoke to Phil Marriott and Humberto Bizzo about a recent paper they published identifying the incorrect use of retention indices in gas chromatography and how this problem can be rectified in practice.
Overcoming Common Challenges to Determine Residual Impurities Using IC in APIs with Limited Water
December 10th 2024Organic solvents are generally not compatible with ion chromatography (IC) systems. The approach presented here assists the use of organic solvents for sample preparation and provides a mechanism for the removal of the organic solvents from the chromatographic flow path.
