Technical Note: Modifying a Standard HPLC Autosampler for On-Line Process Monitoring
Autosamplers for most high performance liquid chromatography (HPLC) systems share characteristic design features: enclosure in relatively small units and sampling operations performed with samples placed inside the autosampler housing. Although these features suffice for most HPLC applications, they limit the versatility of the autosampling operation when sample containers cannot fit inside the unit. In this technical note, the authors describe a simple modification of the standard HPLC autosampler flow path that enables automated sampling and analysis of samples outside the autosampler unit. An added benefit of the modified configuration is that it does not compromise operation in the standard mode, and switching between the two configurations is easy.
LCGC 17(9), 862–864 (1999).
HPLC 2025 Preview: The Present and Future of Automation in Analytical Laboratories
May 22nd 2025Analytical laboratories are undergoing a fundamental transformation. In the face of increasing sample volumes, growing regulatory requirements, and the rising demand for faster, more precise, and cost-efficient analysis, optimizing laboratory processes is becoming a central focus. Automation technologies offer promising solutions in this regard. Recently, they have evolved from isolated solutions to comprehensive systems that permeate nearly all areas of laboratory practice. This development not only opens up new opportunities in terms of efficiency, data quality, and scalability but also brings technical, organizational, and personnel challenges. To successfully address these, strategic approaches are needed that consider both the technological and human dimensions of the transformation.
Quantifying Isavuconazole in Dried Blood Spots Using HPLC
May 21st 2025Isavuconazole, an antimycotic agent used to treat fungal infections, can typically be found during dried blood spot sampling. However, there are obstacles that keep it from being an ideal approach for properly determining the drug’s presence.
HPLC 2025 Preview: On The Road With Your Chromatograph?
Published: May 21st 2025 | Updated: May 21st 2025Brett Paull from the University of Tasmania, Tasmania and his team describe the latest development in portable LC instruments and their experience of taking portable systems out to the field.
