Can a UHPLC approach be easily transferred to speed up GPC/SEC measurements? Unfortunately, the answer is: No! But there are other solutions to make GPC/SEC faster
Ultra-HPLC (UHPLC) provides a new potential for method development and analysis. It is achieved by using a sub-2 µm particle size column packing at increased linear velocities. The advantage of UHPLC over conventional HPLC is the reduced analysis time without sacrificing efficiency. In comparison to traditional HPLC, analysis time can be decreased up to a factor of 7–10.
So the question for GPC/SEC users is: Can this approach be easily transferred to speed up GPC/SEC measurements? Unfortunately, the answer is: No - the UHPLC approach does not work! But there are other solutions to make GPC/SEC faster!
Sustainable Green Solvents in Microextraction: A Review of Recent Advancements
March 27th 2024Conventional sample preparation can be time- and resource-consuming, and a green analytical methodology can be a game-changer for scientists, in addition to facilitating selective and sensitive separations.
Transferring Methods to Compact and Portable HPLC
February 14th 2024The current trend in laboratory equipment design is the miniaturization of laboratory instruments. Smaller-scale HPLC instruments offer benefits that cannot be matched by analytical-scale equipment, especially in the areas of portability, reduced fluid volumes, and reduced operating costs. Yet, the miniaturization of laboratory equipment has brought with it a unique set of challenges, including transferring methods to compact LC. Capillary LC expands the use of LC to applications not currently done using conventional LC in a wide array of application areas, including pharmaceutical, food and beverage, petrochemical, environmental, and oil and gas. Greg Ward, Axcend’s CEO wrote, “Customers want an HPLC system with a small footprint, low flow rates and green chemistry.” Join his podcast where he shares method transfer in these application areas.
High-Throughput Analysis of Volatile Compounds in Air, Water, and Soil Using SIFT-MS (Apr 2024)
March 27th 2024This study demonstrates high-throughput analysis of BTEX compounds from several matrices (air, water and soil). Detection limits in the single-digit part-per-billion concentration range (by volume) are readily achievable within seconds using SIFT-MS, because sample analysis is achieved without chromatography, pre-concentration, or drying. We also present a calibration approach that enables speciation of ethylbenzene from the xylenes in real time.