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Using SRM and H-SRM on an Integrated UHPLC-MS Platform for Sensitive, Accurate and Reproducible Quantification of Perfluorinated Compounds in Human Breast Milk.
Perfluorinated compounds (PFCs) are pollutants that bioaccumulate in animals and humans and have been linked to developmental, reproductive and systemic toxicity. PFCs are detectable in human serum and breast milk and have even been found in the blood of newborns, through lactational transfer from mothers. The potential toxicity and bioaccumulation of these chemicals has led to an increase in the need to monitor PFCs and assess their risk to humans. This article discusses how PFCs can be accurately and reproducibly detected at ppt concentrations in neat solution and human breast milk using selected reaction monitoring (SRM) and highly selective reaction monitoring (H-SRM) on an integrated ultra high performance liquid chromatography mass spectrometry (UHPLC–MS) platform.