Cannabinoids are successfully extracted from a complex brownie matrix using the QuEChERS sample preparation technique, significantly reducing the presence of matrix interferences. The resulting clean samples are analyzed by GC–MS using a specialized deactivated GC column to provide heightened peaks for the cannabinoid compounds.
EPA Method 625 is greatly simplified by using solid phase extraction (SPE) as an alternative to traditional liquid-liquid extraction (LLE). Using this SPE technique, paired with a sensitive GC–MS analysis, increases throughput and data quality, while decreasing manual labor and solvent usage.
Cannabinoids are successfully extracted from a complex brownie matrix using the QuEChERS sample preparation technique, significantly reducing the presence of matrix interferences. The resulting clean samples are analyzed by GC–MS using a specialized deactivated GC column to provide heightened peaks for the cannabinoid compounds.
Improving and optimizing EPA Method 593 using solid phase extraction (SPE) enhances sensitivity and maximizes efficiency while screening by LC–MS-MS for different female birth control hormones present in drinking and waste water.
EPA Method 625 is greatly simplified by using solid phase extraction (SPE) as an alternative to traditional liquid-liquid extraction (LLE). Using this SPE technique, paired with a sensitive GC–MS analysis, increases throughput and data quality, while decreasing manual labor and solvent usage.
Phospholipid removal proves to yield superior results as compared to a traditional protein precipitation step when analyzing a complex plasma matrix via LC–MS-MS. The results displayed a decrease in ion suppression, increased analyte sensitivity, and an improvement in column lifetime.
Enhancing the extraction of vitamins A and E in serum using simplified liquid extraction (SLE) significantly improves the LC–MS-MS detection of target compounds, all while preserving a simple and robust method.
Phospholipid removal proves to yield superior results as compared to a traditional protein precipitation step when analyzing a complex plasma matrix via LC–MS-MS. The results displayed a decrease in ion suppression, increased analyte sensitivity, and an improvement in column lifetime.
Enhancing the extraction of vitamins A and E in serum using simplified liquid extraction (SLE) significantly improves the LC–MS-MS detection of target compounds, all while preserving a simple and robust method.
Using oral fluid as the matrix, a viable and simple solid phase extraction method for a wide range of drugs is developed. Several oral fluid collection devices were evaluated to determine the effectiveness of the cleanup procedure, ultimately confirming that the method is both robust and widely applicable.
Improving and optimizing EPA Method 593 using solid phase extraction (SPE) enhances sensitivity and maximizes efficiency while screening by LC–MS-MS for different female birth control hormones present in drinking and waste water.
Using oral fluid as the matrix, a viable and simple solid phase extraction method for a wide range of drugs is developed. Several oral fluid collection devices were evaluated to determine the effectiveness of the cleanup procedure, ultimately confirming that the method is both robust and widely applicable.
An ultra-sensitive sample preparation technique using solid phase extraction (SPE) microelution 96-well plates effectively concentrates peptides and allows for cleanup of small volume.
A suite of unknown drug compounds from whole blood are analyzed by LC–MS-MS, requiring the need for an effective yet nonspecific cleanup technique. The resulting method demonstrates a simple and fast sample preparation procedure that is suitable for screening many compounds.
A suite of unknown drug compounds from whole blood are analyzed by LC–MS-MS, requiring the need for an effective yet nonspecific cleanup technique. The resulting method demonstrates a simple and fast sample preparation procedure that is suitable for screening many compounds.
An ultra-sensitive sample preparation technique using solid phase extraction (SPE) microelution 96-well plates effectively concentrates peptides and allows for cleanup of small volume.
WAX type columns are the industry standard analyzing a wide range of compounds with polar functional groups. The new Agilent DB-WAX Ultra Inert GC column is presented.
WAX type columns are the industry standard analyzing a wide range of compounds with polar functional groups. The new Agilent DB-WAX Ultra Inert GC column is presented.
Starch is used for a variety of industrial and nu¬tritional purposes. Its functional properties are influenced by the ratio and molar masses of its mac¬romolecular constituents, which vary with source, crop year, and climate. Starch contains large homopolymers of amylose (AMY) and amylopectin (AMP).
This Application Note describes the comparison of complex hop aroma profiles by GC–MS, and the identification of aroma-active terpenoids aided by soft electron ionisation.
This Application Note describes the comparison of complex hop aroma profiles by GC–MS, and the identification of aroma-active terpenoids aided by soft electron ionisation.
An effective analytical method for detecting pesticide residues in olive oil
The resolution, sensitivity, and mass accuracy of the Agilent 7200 GC/Q-TOF system provide rapid, simple, and reliable analysis of trace levels of sulfur compounds in coffee.
The automated derivatization of fatty acids (FAs) was performed with the Agilent 7696A Sample Prep WorkBench. Since free fatty acids show tailing in gas chromatography, transformation of fatty acids into fatty acid methyl esters (FAMEs) is widely used.
Polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) are fat-soluble, highly toxic, ubiquitous environmental contaminants found at trace levels in all foodstuffs and animal feed.
Most recently formulated pesticides are smaller in molecular weight and designed to break down rapidly in the environment.
SPME-GC–MS with on-column injection can be successfully employed for flavour profiling of food samples. The on-column injector of the GC-2010 can be used for SPME without any modifications, only an external ring adapter was used to facilitate the injection. The data can be compared with sensorial data of food.
The composition and analysis of fragrance components in home and personal care (HPC) products is very complex and unquestionably time consuming.
The QuEChERS method for pesticide analysis was first introduced by USDA scientists in 2003. The EN method 15662:2007 is a European variation to the QuEChERS method. The method uses acetonitrile extraction, followed by the salting out of water from the sample using anhydrous magnesium sulphate (MgSO4, NaCl and buffering citrate salts to induce liquid–liquid partitioning.
The separation of structurally diverse analytes is often complicated by chance coelutions with other analytes or with matrix related compounds. Often the column is blamed, but while such coelutions make analysis difficult they do not necessarily indicate a faulty column, poor chromatography or method design.
