Application Notes: GC

In food safety testing, instrument reliability under real-world conditions is the true test of performance. This technical note showcases the durability and consistency of the PerkinElmer QSight® 500 LC/MS/MS system through an intensive robustness study, analyzing high-matrix food samples with minimal cleanup and no loss in sensitivity. Using a simplified QuEChERS extraction (no SPE), the system successfully analyzed PFAS analytes across complex matrices like salmon, avocado, pet food, and spices. The results highlight not only long-term stability but also the power of StayClean™ technology to reduce downtime and keep throughput high.

This application note describes a fast and robust LC‑MS/MS method for honey authenticity testing by targeted quantification of 3‑methoxytyramine, a specific marker for beet‑sugar feeding. Using the QSight® 500 LC‑MS/MS with EDIT‑ESI and a simplified Blend‑and‑Inject workflow, the method eliminates SPE and isotopically labeled internal standards while delivering high sensitivity, excellent reproducibility, and high throughput for routine commercial and regulatory honey testing.

This application note presents a simplified Blend‑and‑Inject LC‑MS/MS method for the quantification of 25 PFAS compounds in animal‑derived food matrices using the QSight® 500 LC‑MS/MS system. By eliminating SPE and leveraging matrix‑matched calibration, isotopically labeled standards, and a PFAS delay column, the method achieves EU‑compliant sensitivity and robust performance in complex tissues, enabling high‑throughput and reliable PFAS monitoring for food safety compliance.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

GC-FID enables fast, reproducible analysis of 37 FAMEs in edible oils, improving fatty acid profiling for quality, authenticity, and adulteration detection.

HS-GC-FID enables compliant residual solvent analysis per USP 467, delivering accurate quantitation, full separation, and improved productivity in pharma labs.

A robust HS-GC-FID workflow on the PerkinElmer GC system enables accurate, reproducible USP 467 residual solvent analysis with streamlined, 21 CFR Part 11–compliant data control.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using the PerkinElmer GC system, ensuring compliance, sensitivity, and resolution.

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

For sulfur compounds in the sub-ppmv to ppbv and lower concentrations, dynamically generated gas standards prevent the need for storing reactive and unstable components

Actively recording calibration gas data... creates unique advantages over traditional cylinder gas calibration.

VUV’s diesel fuel application enables rapid, automated measurement of saturates, aromatics, PAHs, and FAMEs in a single GC–VUV run using ASTM D8368. This direct-injection method requires no sample prep or calibration curves, delivers class-based spectral validation, and provides accurate results in under 30 minutes

VUV’s GC–VUV platform with ASTM D8267 enables rapid, automated measurement of total, mono-, and diaromatic content in jet fuel with superior precision and reproducibility compared to FIA and HPLC. This direct-injection method requires no sample prep or calibration curves, delivers results in 14 minutes, and significantly lowers cost per analysis

VUV’s GC–VUV platform with ASTM D8071 enables fast, automated PIONA and multi-parameter gasoline analysis in a single run. It delivers superior precision and reproducibility compared to traditional methods, requires no sample prep or calibration curves, and consolidates multiple regulatory tests into one cost-efficient workflow

Demonstrate reliable measurement of water at trace levels and beyond in acetonitrile using gas chromatography (GC) combined with the LUMA Multi-Channel Vacuum Ultraviolet (VUV) Absorbance detector. Additionally, we will demonstrate the ability of LUMA to detect water and multiple solvents in a single analysis.

Discover how the PerkinElmer GC 2400™ Platform helps with the residual solvent in plastic with accuracy and sensitivity, providing reliable and reproducible runs for high throughput laboratories.

Discover how the PerkinElmer GC 2400™ Platform provides fast analysis and high reproducibility.

Read how the integrated HS-GC workflow allows a continuous optimization of the pneumatic values for ultimate precision in GC retention time.

Discover an optimized GC/MS approach for SVOC in complex matrices.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

Discover the GC 2400™ Platform for analytical precision and robustness for fuel alcohol analysis over a wide range of sample concentrations.

Read about compliant analysis for the determination of ethanol and methanol content in fuels.

Discover an optimized GC/MS method conditions allowing faster analysis and increased throughput.

Read about this fast method providing excellent resolution and highly repeatable separations contributing to improve data quality while increasing lab productivity.

Discover how the PerkinElmer GC 2400™ Platform provides high level of precision for VOC analysis in paint.

Discover fast, robust, and sensitive analysis of alcohol in food with a new GC user-experience.

Discover an easy method that can help meet the most stringent purity requirements.