Authors

How Green Is Your Method? Evaluating the Sustainability of Analytical Methods

With the increasing interest in green chemistry and sustainability, analytical chemists are developing new methods and reexamining existing methods with a new emphasis on sustainability and environmental impact. Since the publication of the principles of green chemistry in the 1990s and the principles of green analytical chemistry in the 2000s, several scoring systems for evaluating the greenness or sustainability of analytical methods have been developed. In this column, we will examine three widely used scoring methods: Red, green blue (RGB), the analytical greenness metric (AGREE), and the analytical method greenness score (AMGS) with comments on how they all apply to gas chromatography (GC). We will see that classical GC, which has roots in the origins of the environmental movement, has been and remains among the greenest of analytical techniques.

HPLC 2025 Preview: Prioritization Strategies in Non-Target Screening of Environmental Samples by Chromatography with High-Resolution Mass Spectrometry

This article discusses how integrating seven prioritization strategies can enhance compound identification, support environmental risk assessment, and accelerate decision-making.

Toward Better Detection of PFAS in Consumer Electronic Products: Optimizing the Accuracy of a Total Fluorine Test Method in Materials Containing Polymeric PFAS

The aim of this article is to provide a validated and optimized CIC-based method for accurate measurement of total fluorine in materials with polymeric PFAS content in the low-ppm range, which could be used in the consumer electronics and potentially other industries. This, in turn, can aid companies in tracking and mitigating PFAS ahead of regulations.

Toward Better Detection of PFAS in Consumer Electronic Products: Optimizing the Accuracy of a Total Fluorine Test Method in Materials Containing Polymeric PFAS

The aim of this article is to provide a validated and optimized CIC-based method for accurate measurement of total fluorine in materials with polymeric PFAS content in the low-ppm range, which could be used in the consumer electronics and potentially other industries. This, in turn, can aid companies in tracking and mitigating PFAS ahead of regulations.

Emerging Tools for Holistic Evaluation of Analytical Methods

The RGB model, which combines red (analytical performance), green (environmental impact), and blue (practicality), is at the heart of the concept of white analytical chemistry (WAC). While this approach has helped broaden the field’s focus and offered a more balanced evaluation system, analytical science continues to move forward, and with it come new priorities that extend beyond what the RGB framework can fully reflect. This final article of this week's series on WAC curated by Adrián Fuente-Ballesteros of the University of Valladolid (Spain) presents new tools intended to fill that gap.

The Importance of Rapidly Accessing Reliable Analytical Consumables

This blog provides an overview of some real-world issues and examples contributing to analytical downtime and how these can be remedied.

HPLC 2025 Preview: Prioritization Strategies in Non-Target Screening of Environmental Samples by Chromatography with High-Resolution Mass Spectrometry

This article discusses how integrating seven prioritization strategies can enhance compound identification, support environmental risk assessment, and accelerate decision-making.

Retaining Talent in Field-Flow Fractionation: An Initiative

The authors present their motivation for establishing the Young Scientists of FFF (YSFFF) initiative within the FFF community.

Event Preview: SFC/SFE Japan 2026

Discover the latest advancements in supercritical fluid chromatography and extraction at SFC/SFE Japan 2026.

Advances in Spatial Biology using TIMS-TOF MS

A look at the practical benefits of using TIMS-TOF MS in spatial biology applications.

Design of a 3D-Printed Needle-Plate Ion Source for High Field Asymmetric Waveform Ion Mobility Spectrometry

A new paper presents the design of a needle-plate dielectric barrier discharge DBD ion source based on 3D printing for high field asymmetric-waveform ion-mobility spectrometry (FAIMS).

Overcoming Limitations in Food Analysis with Cryogen-free Trap Focusing: Enhancing Sensitivity, Selectivity, and Throughput

Trap focusing offers a powerful solution to common challenges in headspace (HS) and solid-phase microextraction–gas chromatography (SPME–GC) analysis of foodstuffs, including poor peak shape, limited sensitivity, and restricted dynamic range. This article explores how automated cryogen-free focusing, combined with multi-step enrichment and re-collection capabilities, can improve the detection and quantitation of both aroma-active compounds and trace-level contaminants. Using real-world examples, including flavor profiling of cola and garlic, and quantitation of ethylene oxide and epichlorohydrin in spices, enhanced chromatographic performance, greater confidence in compound identification, and lower detection limits than traditional workflows such as direct SPME or QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) are demonstrated.

Boosting Untargeted Benchtop Volatilomics to the Next Level: Chiral Trapped-Headspace GC-QMS-IMS

The approach describes a new untargeted, trapped-headspace (THS)-GC-QMS-IMS setup for an exhaustive VOC analysis of complex food, beverage, and flavor products, and allows the classification of mango cultivars in combination with chemometric data evaluation.

A Practical Excel Tool to Support the Development of Comprehensive 2D-LC Separations

An Excel-based tool has been developed to help users understand the fundamentals of comprehensive 2D-LC.

Retaining Talent in Field-Flow Fractionation: An Initiative

The authors present their motivation for establishing the Young Scientists of FFF (YSFFF) initiative within the FFF community.

Capillary Column Technologies: Efficiencies, Throughput, Reproducibility, and What’s Next?

Key aspects involved in manufacturing high-quality packed capillary columns, including fritting, column packing, and parallel fabrication, are discussed.

Retaining Talent in Field-Flow Fractionation: An Initiative

The authors present their motivation for establishing the Young Scientists of FFF (YSFFF) initiative within the FFF community.

Accelerating Monoclonal Antibody Quality Control: The Role of LC–MS in Upstream Bioprocessing

This study highlights the promising potential of LC–MS as a powerful tool for mAb quality control within the context of upstream processing.

Static Light Scattering Detectors in GPC/SEC: How Many Angles Do I Need?

This installment of Tips & Tricks focuses on the determination of the molar mass using a light scattering detector as an absolute detection method.

Expanding Fuels Analysis to Pyrolysis Oils: Inside ASTM D8519 and VUV Technology

Sean Jameson, SVP of Business Development at VUV Analytics, discusses the newly released ASTM D8519 method. This method extends established VUV-based hydrocarbon analysis into the pyrolysis oil range, enabling automated, scalable characterization of complex recycled and biomass-derived feedstocks up to C64.

Emerging Tools for Holistic Evaluation of Analytical Methods

The RGB model, which combines red (analytical performance), green (environmental impact), and blue (practicality), is at the heart of the concept of white analytical chemistry (WAC). While this approach has helped broaden the field’s focus and offered a more balanced evaluation system, analytical science continues to move forward, and with it come new priorities that extend beyond what the RGB framework can fully reflect. This final article of this week's series on WAC curated by Adrián Fuente-Ballesteros of the University of Valladolid (Spain) presents new tools intended to fill that gap.

Retaining Talent in Field-Flow Fractionation: An Initiative

The authors present their motivation for establishing the Young Scientists of FFF (YSFFF) initiative within the FFF community.

Mastering Chromatography Method Transfer in Today’s Connected World

A look at today’s outsourcing scale, examining market dynamics around chromatography, distilling pain points and user requirements, and presenting evidence that digital, standardized method transfer can reduce risk, speed technology transfer, and improve quality, ultimately accelerating time‑to‑market.

The Role of mD-LC–MS for Antibody Analysis in the Biopharmaceutical Industry

How is mD-LC–MS changing the way we evaluate HPLC peaks and assess performance?

Addressing the (EU) 2020/2184 Directive for the Performant Determination of Polar and Non-Polar Pesticide Panels Using a Common Reverse Phase LC-MS/MS Configuration