Although gel permeation chromatography (GPC) is not as widely used as other chromatography methods, it continues to be a useful technique for analyzing the size and solution characteristics of organic polymers. In this study, GPC was applied to analyze different polar polymers that are commonly used in drug excipients. As a result of their polarity, some specialized operating conditions were required. Optimizing the separation brought to light many of the common parameters involved in optimizing GPC separations, and those are discussed in detail here.
The current state of economic affairs is tumultous; as the economy struggles to bounce back, companies across all industries are becoming more creative in finding ways to reduce costs without sacrificing the quality of their goods or services. According to a recent survey conducted by the Society of Forensic Toxicologists (SOFT), 64.5% of forensic labs surveyed are implementing changes, or plan to implement changes, as a result of limited resources.
A method is illustrated for the simultaneous analysis of ethyl glucuronide and ethyl sulfate in human urine samples.
Barbiturates are a class of antidepressants whose abuse and addiction by recreational users has become a widespread problem (www.nlm.nih.gov). In our work we strived to streamline the barbiturate screening process to provide a fast, cost-effective, and reproducible method from start to finish for forensic labs who are involved in high-throughput processing.
In pain management analysis, urine is often used as it is a copiously available bodily fluid that can be collected easily and used for analysis.
Fast turnaround time is critical in the clinical testing environment. Here, fast liquid chromatography (LC) technologies were utilized for the comprehensive assay of commonly prescribed pain management drugs in under 2 min. The use of fast LC also provided significantly improved sensitivity. A mini-validation for these analytes in human urine was performed and acceptable values for accuracy, precision, linearity, lot-to-lot variability, and matrix effects were demonstrated for each analyte.