July 2024

Researchers at the Cleveland Clinic, using liquid chromatography tandem mass spectrometry (LC-MS/MS), determined that xylitol may be a risk factor related to a major adverse cardiovascular event.

This article describes a comprehensive study on optimizing ion-pair reversed-phase liquid chromatography for analysing protected and unprotected single-stranded DNA oligonucleotides.

LCGC International spoke to Jeffrey Zonderman, Senior Vice President of Bruker Applied MS, about current trends in mass spectometry and moving to a “chromatography-free” world.

This article explores three case studies where autosampler injection programs help to (i) reduce the carry-over observed for large nucleic acids during anion-exchange chromatography (AEX), (ii) reduce peak distortion and breakthrough for monoclonal antibodies (mAbs) during hydrophilic-interaction chromatography (HILIC), and (iii) facilitate dissolution of lipid nanoparticles (LNPs) so that a size-exclusion chromatography (SEC) method can be applied for ribonucleic acid (RNA) payload analysis.

LCGC International spoke with Shawn Anderson, Associate Vice President of Digital Lab Innovations at Agilent Technologies; Marco Kleine, Head of the Informatics Department at Shimadzu Europa GmbH; Trish Meek, Senior Director, Connected Science, Waters Corporation and Todor Petrov, Senior Director, QA/QC, Waters Corporation; and Crystal Welch, Product Marketing Manager at Thermo Fisher Scientific about the latest trends in data handling.

Scientists from the University of Turin, Italy have learned how to combine their complementary competencies in analytical chemistry and big data analytics to achieve significant advances in food science and health.

Click here to open The Column July 2024 Europe issue, Volume 20, Number 7, in an interactive PDF format.

Click here to open The Column June 2024 North America issue, Volume 20, Number 7, in an interactive PDF format.