LCGC Europe-04-01-2005

In this month’s column, John Dolan addresses a reader’s peak-splitting problem and suggests ways to avoid such occurrences in the future.

In this article, Jo Webber tackles the problem of ensuring data integrity in pharmaceutical manufacturing. She shows how, by using modern technology and well integrated systems, quality can be improved.

In the first part of this series, the authors look at method modification from a scientific and regulatory standpoint with regard to changing a column and the operating parameters.

The authors explain how to construct box plots and how they can help you to learn more about your data.

In this article, the authors describe a method based on the accelerated and automated extraction of hexavalent chromium from solid samples followed by ion chromatography analysis using spectrophotometric detection. The experiments were performed on different samples of sludge and soil.

This month’s column provides an overview of several recently developed technologies that aim to improve the utility and performance of mass spectrometers in a number of applications.