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LCGC Europe-06-01-2005
LCGC Europe
HPLC Analysis of Non-volatile Analytes Using Charged Aerosol Detection
June 01, 2005
Charged Aerosol Detection
18
6
A detection method based upon aerosol charging was examined for its applicability and performance with high performance liquid chromatography.
Separating Proteins by pI-Values — Can 2D LC Replace 2D GE?
June 01, 2005
Protein Separation
18
6
The authors address the specific separation problems of proteins and assess whether 2D liquid chromatography could possibly be considered as an alternative to traditional 2D gel electrophoresis in the future.
Profiles in Practice Series: Metabolism Identification and Structural Characterization in Drug Discovery
June 01, 2005
MS in Practice
18
6
In this initial instalment, several MS technologies and strategies currently being applied to characterize drug candidates in early stage development are presented.
Adjusting Conditions for a Routine Reversed-Phase HPLC Assay, Part 2: Changing Separation Conditions
June 01, 2005
Column Watch
18
6
In the last part of this series, the authors provide a technical review of the means for method adjustment and the pertinent regulations concerning the required validation of adjusted methods.
Overload or Minor Peak
June 01, 2005
LC Troubleshooting
18
6
This month, John Dolan offers some suggestions for distinguishing between overload and the presence of a minor peak.
Determining the Hydrocarbon Oil Index in Water using Ultra Fast Gas Chromatography
June 01, 2005
Gas Chromatography
18
6
This article discusses utra fast gas chromatography as a suitable technique for determining the hydrocarbon oil index in water. The advantages of this technique over conventional GC technology are presented.