LCGC Europe-06-01-2005

Charged Aerosol Detection
LCGC Europe

June 01, 2005

A detection method based upon aerosol charging was examined for its applicability and performance with high performance liquid chromatography.

Protein Separation
LCGC Europe

June 01, 2005

The authors address the specific separation problems of proteins and assess whether 2D liquid chromatography could possibly be considered as an alternative to traditional 2D gel electrophoresis in the future.

In this initial instalment, several MS technologies and strategies currently being applied to characterize drug candidates in early stage development are presented.

In the last part of this series, the authors provide a technical review of the means for method adjustment and the pertinent regulations concerning the required validation of adjusted methods.

LC Troubleshooting
LCGC Europe

June 01, 2005

This month, John Dolan offers some suggestions for distinguishing between overload and the presence of a minor peak.

This article discusses utra fast gas chromatography as a suitable technique for determining the hydrocarbon oil index in water. The advantages of this technique over conventional GC technology are presented.