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LCGC Europe-06-01-2005

LCGC Europe

HPLC Analysis of Non-volatile Analytes Using Charged Aerosol Detection

June 01, 2005

Charged Aerosol Detection

18

6

A detection method based upon aerosol charging was examined for its applicability and performance with high performance liquid chromatography.

Separating Proteins by pI-Values — Can 2D LC Replace 2D GE?

June 01, 2005

Protein Separation

18

6

The authors address the specific separation problems of proteins and assess whether 2D liquid chromatography could possibly be considered as an alternative to traditional 2D gel electrophoresis in the future.

Profiles in Practice Series: Metabolism Identification and Structural Characterization in Drug Discovery

June 01, 2005

MS in Practice

18

6

In this initial instalment, several MS technologies and strategies currently being applied to characterize drug candidates in early stage development are presented.

Adjusting Conditions for a Routine Reversed-Phase HPLC Assay, Part 2: Changing Separation Conditions

June 01, 2005

Column Watch

18

6

In the last part of this series, the authors provide a technical review of the means for method adjustment and the pertinent regulations concerning the required validation of adjusted methods.

Overload or Minor Peak

June 01, 2005

LC Troubleshooting

18

6

This month, John Dolan offers some suggestions for distinguishing between overload and the presence of a minor peak.

Determining the Hydrocarbon Oil Index in Water using Ultra Fast Gas Chromatography

June 01, 2005

Gas Chromatography

18

6

This article discusses utra fast gas chromatography as a suitable technique for determining the hydrocarbon oil index in water. The advantages of this technique over conventional GC technology are presented.