LCGC Europe-10-01-2008

Very short columns filled with 1.9 µm particles were evaluated for the ultra-fast analysis of pharmaceutical formulations. Local anæsthetic, mydriatic and anti-hypertensive agents were chosen as analytes and a method was developed and validated for each of these substances, according to ICH guidelines. Excellent quantitative performance was obtained using an optimized chromatographic system that reduces the importance of extra-column effects and cuts the analysis time to less than 15 s.

Do sticky check valves have you discouraged?

The regulatory world and associated guidance documents within the pharmaceutical industry is changing rapidly. This column gives an overview of what's happened since the start of the year.

Small Molecule Talk; On-line video for biological sample concentration; Digital Pen for BlackBerry Smartphones

Microemulsion liquid chromatography (MELC) is a recent development offering reduced sample preparation times for complex samples and generic separation conditions applicable to a wide range of solutes. This article introduces the concepts of MELC and discusses the possible benefits and future applications.

The 25th anniversary of the Montreux LC–MS symposium will be held at the Montreux Music and Convention Centre, Montreux, Switzerland from 12–14 November 2008.