October 2022

Some liquid chromatography (LC) troubleshooting topics never get old because there are some problems that persist in the practice of LC, even as instrument technology improves over time. There are many ways for things to go wrong in an LC system that ultimately manifest as detector baselines that do not look right. Developing a short list of the likely causes of these results can help streamline our troubleshooting experience when baseline-related problems occur.

The term orphan data is used frequently in the context of data integrity. What does it mean for chromatography data systems? How can we prevent or detect orphan data?