December 2021 | LCGC North America

Analysis of Boronic Compounds as Potential Mutagenic Impurities in Drug Substances By GC–MS

December 01, 2021

Peer-Reviewed Article

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This novel gas chromatography (GC)–MS approach enables analysis of the suspected mutagens bis(pinacolato)diboron (BPD) and tetrahydroxydiboron (BBA) found at low-levels in certain intermediates and active pharmaceutical ingredients (APIs), even in the presence of boron from other sources.

LCGC Employment and Salary Survey 2021: A Year of Recovery—Pandemic, Back to the Office, Economic Changes, Hybrid Meetings, and More

December 01, 2021

Feature Article

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Our annual LCGC salary survey takes a look at employment conditions, salary, benefits, and other workplace concerns affecting scientists and technicians working in the chromatography and separation sciences field, and assesses where things stand after more than 18 months since the start of the coronavirus pandemic.

Don’t Fear the Automation

December 01, 2021

Columns

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Are we ready to let software and instruments take over the art of separations?

The Use of Molecular Imprinted Polymers Prior to Chromatographic Methods for the Analysis of Bisphenols in Packaged Foods

December 01, 2021

Columns

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We examine the rapid growth of green microextraction techniques, such as molecular imprinted polymer solid-phase extraction (MISPE), in the field of food quality and safety, and how this technique is used for bisphenol A (BPA) analysis.

A Rapid, Automated Extraction Platform to Assess Drug Product Potency by Online Liquid Chromatography

December 01, 2021

Column: Column Watch

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Here, a new automated active pharmaceutical ingredient (API) extraction platform is integrated with online liquid chromatography (LC) to assess drug product potency. The platform dissolves the tablet coating (if present), disintegrates the tablet, and disperses and solubilizes the tablet for analysis.

Essentials of LC Troubleshooting, Part I: Pressure Problems

December 01, 2021

Column: LC Troubleshooting

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Deviations from the expected pressure in modern LC systems (too low, too high, or fluctuating) can be diagnosed and more quickly resolved using the streamlined troubleshooting practices shown here.