LCGC North America-01-01-2014

The Australian Patent Office has granted a patent related to W. R. Grace & Company's (Columbia, Maryland) Reveleris flash chromatography system.

Secondary parameters in the interface and mass analyzer can have a major impact on sensitivity and reproducibility. Here, we examine how and when to consider optimizing these parameters through a study of the working principles of LC–MS analysis.

We assessed a simple method based on recovery for the detection of matrix effects and two alternative methods for the rectification of matrix effects in LC–MS: standard addition and the coeluting internal standard method.

The modern usage and specific applications of HILIC for two other major classes of analytes - glycopeptides and glycoproteins - are discussed.

What good is that big, ugly peak at the beginning of the chromatogram?

A look at five sample preparation methods where the application of a charge across barriers provides enhanced selectivity

We track the genesis of the top four carrier gases before they start their journey through a GC system.

Click the title above to open the LCGC North America January 2014 regular issue, Vol 32 No 1, in an interactive PDF format.