April 2021

To achieve the best selectivity and recovery in liquid–liquid extraction (LLE), a few fundamentals need to be clearly understood.

Pyrolysis–gas chromatography–mass spectrometry has advantages for the analysis of environmental microplastic samples compared to other leading analytical methods, including spectroscopic techniques.

Highlights of the new high-performance liquid chromatography, mass spectrometry, and chromatography data systems introduced over the past year.

We present our annual review of new products in gas chromatography, introduced between spring 2020 and spring 2021.

Dispersion of analyte zones outside of the column often compromises the quality of an LC separation—particularly in smaller columns with smaller particles. We explain basic concepts in extra-column dispersion from the point of view of an entire instrument.

Erik Regalado is constantly developing and implementing enabling technologies for pharmaceutical development—such as automated methods, ultrafast and computer-assisted analysis, and multidimensional chromatography.

We assess recent advances in cleaning verification methods for small-molecule pharmaceuticals, and propose a workflow.