April 2021 | LCGC North America

Strategies for Optimization of Liquid–Liquid Extraction (LLE) Protocols

April 07, 2021

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To achieve the best selectivity and recovery in liquid–liquid extraction (LLE), a few fundamentals need to be clearly understood.

Identification of Microplastics in Environmental Monitoring Using Pyrolysis–GC–MS Analysis

April 07, 2021

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Pyrolysis–gas chromatography–mass spectrometry has advantages for the analysis of environmental microplastic samples compared to other leading analytical methods, including spectroscopic techniques.

New HPLC, MS, and CDS Products Introduced in 2020–2021: A Brief Review

April 07, 2021

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Highlights of the new high-performance liquid chromatography, mass spectrometry, and chromatography data systems introduced over the past year.

New Gas Chromatography Products for 2020–2021

April 07, 2021

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We present our annual review of new products in gas chromatography, introduced between spring 2020 and spring 2021.

Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part I: Basic Concepts

April 07, 2021

Columns

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Dispersion of analyte zones outside of the column often compromises the quality of an LC separation—particularly in smaller columns with smaller particles. We explain basic concepts in extra-column dispersion from the point of view of an entire instrument.

Accelerating the development of new pharmaceuticals: Erik Regalado, the 2021 winner of the Emerging Leader in Chromatography Award

April 01, 2021

Featured Article

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Erik Regalado is constantly developing and implementing enabling technologies for pharmaceutical development—such as automated methods, ultrafast and computer-assisted analysis, and multidimensional chromatography.

Combined Chromatographic and Spectrometric Approaches for Cleaning Verification of Small-Molecule Pharmaceutical Compounds in the Manufacturing Environment

April 01, 2021

Peer-Reviewed Article

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We assess recent advances in cleaning verification methods for small-molecule pharmaceuticals, and propose a workflow.