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November 2022 | LCGC North America
Pitfalls in Proteomics: Avoiding Problems That Can Occur Before Data Acquisition Begins
November 01, 2022
Column: LC Troubleshooting
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Knowing the tips and tricks of producing quality LC–MS data for peptide analysis can help streamline troubleshooting when problems occur.
Class Is Back in Session: More Questions on Your Extraction Knowledge
November 01, 2022
Column: Sample Prep Perspectives
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Test your knowledge of octanol-water partition coefficients and practical applications of sample preparation.
Selectivity and Sensitivity: The Electron Capture Detector (ECD), Its Unique Inventor James Lovelock (1919–2022), and GAIA
November 01, 2022
Column: GC Connections
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The electron capture detector (ECD) for GC is still used relatively unmodified today. But using it effectively means understanding the tradeoffs between selectivity, ease of use, and sensitivity.
On Replication in Biopharmaceutical Analysis
November 01, 2022
Column: Focus on Biopharmaceutical Analysis
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What is the right number of replicates in biopharmaceutical analysis? Does the answer depend on the type of analysis?
Tools for Investigating the Expanding Per- and Polyfluoroalkyl Substances (PFAS) Universe
November 01, 2022
Columns
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With suspect PFAS screening becoming more popular, and the list of known PFAS now in the thousands, novel analytical tools are needed to generate transferable data sets. We highlight key updates here.
Sample Preparation by Electric Field–Assisted Extraction
November 01, 2022
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Integrating electric fields into extraction techniques increases sensitivity and selectivity. These approaches are compatible with miniaturized, portable, and many biological samples.
Overcoming Incomplete Peptide Mapping of Antibody Complementarity-Determining Regions with Alternate Digestion Workflows
November 01, 2022
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Pepsin digestion and guanidine hydrochloride post-digestion can improve sequence coverage in antibody peptide mapping compared with trypsin digestion.