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The use of HPLC for determining amphetamines has not received much attention because of the poor response of UV spectrometric detectors to these compounds when present at low concentration levels. However, HPLC coupled with mass spectrometry can provide the sensitivity required for the analysis of analytes at low concentrations in biological samples. In comparison to GC–MS and LC-UV analyses, LC–MS–MS offers superior sensitivity, selectivity and robustness for a wide range of analytes without any need for derivatization. LC–MS–MS technology also makes possible the development of highly selective, sensitive and precise methods for the simultaneous analysis of amphetamines and their metabolic derivatives. In combination with LC–MS–MS, limits of quantitation (LOQ) of 0.54 ng/mL are achieved for MAMPH, HMMA, and MDMA and LOQ of 1.0 ng/mL are achieved for AMPH and MDA on Gemini C18 HPLC columns.

Varian, Inc. has published an application note entitled Separation of Trichlorobenzene from Sardines using EcoSpheres. This note illustrates how EcoSpheres can be used to assess contaminant levels in environmental samples.

HPTLC Determination of Polycyclic Aromatic Hydrocarbons in Mussels After a Crude Oil Spill in Chile Victor H. Campos, Katherine MuÖoz, Elizabeth Jara, Patricia Gonzalez, Mario Aranda and Mario Vega. Characterizing the Secreted Proteome of Mycobacterium Tuberculosis by LC–MS–MS Matthew M. Champion and Patricia A. DiGiuseppe Champion Meeting Review Pittcon 2009 This year's president, Ed Ladner, reflects on the success of Pittcon 2009 and demonstrates how the struggling global economy didn't take the shine away from its 60th celebration. News Protecting the Florida Everglades, securing nitrogen supplies, developments in ice chromatography and a discovery involving cheese are in the news this month. Incognito Pittcon Pioneers... After returning from Pittcon this year a little deflated by the lack of inspiration on offer, Incognito calls for a return to the inventive spirit and urges all entrepreneurs to demonstrate their creativity. Market Trends and Analysis Market Profile: Automated Peptide/Protein Sequencers Glenn Cudiamet Tips and Tricks: GPC/SEC How to choose a Static Light-Scattering Technique for the Molar Mass Determination Daniela Held and Peter Kilz Q&A It's a Small World The Column spoke to Job Elders of C2V about developments in micro gas chromatography.

Rapid Analysis of Limonin Citrus Extract Using U-HPLC-Hitachi Application Note

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In this article, the authors discuss the need for protection against chemical attacks and the role of passive imaging spectroradiometers in the detection of remote chemical agents.

Application of Novel Ethylene Bridged Hybrid Particles for Hydrophilic Interaction Chromatography- Waters Application Note

The use of mass spectrometry to study biofuels is examined and the advantages and disadvantages are explored.

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Application of Novel Ethylene Bridged Hybrid Particles for Hydrophilic Interaction Chromatography- Waters Application Note

Analysis of Products Containing the Sweetener Stevia-ESA Application Note

Researchers from Universitat Rovira i Virgili (Tarragona, Spain) and the University of Strathclyde (Glasgow, UK) synthesized two molecularly imprinted polymers (MIPs) by precipitation polymerization using the antiepileptic drug carbamazepine as the template molecule and two types of crosslinking agents.

Addressing the Acetonitrile Shortage-Waters Application Note

A Robust Validation Method for Guanidine-Microsolv Application Note

Fentanyl Quantitation Using Online High-throughput System-Thermo Application Note

Optimizing Sensitivity and Selectivity for the Analysis-Phenomenex Application Note

Scientists from the New Jersey Institute of Technology (Newark, New Jersey) used micro solid-phase extraction (SPE) devices consisting of single- and multiwalled carbon nanotubes packed in the needle of a syringe for sampling, analyte enrichment, and sample introduction.

Euroanalysis 2009, which is organized under the umbrella of the Division of Analytical Chemistry (DAC) of the European Association for Chemical and Molecular Sciences (EuCheMS), has become a premier event for scientists to discuss and hear presentations on a broad spectrum of analytical techniques from a diverse range of applications. Euroanalysis aims to bring together analytical chemists from various fields to stimulate communication and strengthen networks in analytical sciences.

A researcher from the National University of Kaohsiung (Kaohsiung, Taiwan) used micellar electrokinetic chromatography (MEKC) to preconcentrate and separate gold nanoparticles.

Researchers from Central China Normal University (Wuhan, China), Wenzhou Medical College (Wenzhou, China), and East China University of Science and Technology (Shanghai, China) extracted polybrominated diphenyl ethers (PBDEs) from water and plant samples using solid-phase extraction (SPE) and dispersive liquid?liquid microextraction (DLLME).

"...We will restore science to its rightful place, and wield technology's wonders to raise healthcare's quality and lower its cost. We will harness the sun and the winds and the soil to fuel our cars and run our factories...." - President Barack Obama, 44th President of the US, Inaugural address, 20 January 2009, Washington, DC.

Deciding on a zero intercept.

Phenomenex Inc. (Torrance, California) raised raised $5,150 for Cheer for Children, a Redondo Beach based non-profit that raises donations to help acutely ill children and their siblings at County-Harbor UCLA Medical Center and for children with orthopedic disabilities at local schools, through a combination of sporting challenges, raffles, and refreshment sales.

Analysis of Parabens Using the Prep-24 Dual Piston Pump-Hitachi Application Note

Scientists from Lorillard Tobacco Company (Greensboro, North Carolina) developed an improved method for analyzing polycyclic aromatic hydrocarbons (PAHs) in mainstream tobacco smoke.

Researchers from Amgen (Thousand Oaks, California) examined the separation mechanism in the analysis of polar and basic hydrazines using hydrophilic interaction liquid chromatography (HILIC) with alcohol rather than acetonitrile as a weak eluent.

Monitoring Protein Modifications of the Biogeneric Protein Interferon-Phenomenex Application Note

Researchers from Zhejiang Province Environmental Monitoring Centre (Zhejiang, China) and Xiangtan University (Hunan, China) developed an ultrahigh-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS-MS) method for analyzing alkylphenols in soil.