July 26th 2024
Here are the top five articles published on LCGC International this week.
Evaluating Marine Algae for Therapeutic Effects
May 15th 2018Snezana Agatonovic-Kustrin, a professor in pharmaceutical chemistry at Monash University, in Kuala Lumpur, Malaysia, spoke to The Column about the development of a method to evaluate antidiabetic and antioxidant activity in marine algae using high-performance thin-layer chromatography (HPTLC)-direct bioautography.
Determining the Presence of Ancient Cereals Using GC–MS AND HPLC–MS
March 20th 2018The Column spoke to Erika Ribechini, Associate Professor of analytical chemistry in the Department of Chemistry and Industrial Chemistry of the University of Pisa, Italy, about her research into cereals in ancient diets and the role of chromatography in establishing their importance.
LCGC’s 2018 Emerging Leader Award in Chromatography Winner: Zachary S. Breitbach
March 13th 2018Zachary S. Breitbach, the 2018 winner of the LCGC Emerging Leader in Chromatography award, received his PhD in 2010 from the University of Texas at Arlington (UTA). Subsequently, he worked as a research scientist at UTA while simultaneously aiding in the launch of AZYP Separations and Analytics, a chromatographic materials company. Currently, he is a senior scientist at AbbVie. Breitbach has already made important contributions to both high performance liquid chromatography (HPLC) and gas chromatography (GC). In GC, he played a fundamental role in the development, synthesis, characterization, and utilization of highly thermally stable, high viscosity ionic liquids as new GC stationary phases. Two of the ionic liquids he developed were subsequently commercialized. In HPLC, his work covers enantiomeric separations, hydrophilic interaction chromatography (HILIC), ultrafast and high efficiency separations, supercritical and subcritical fluid separations, core–shell bonded phases, and interfacing HPLC to paired io
The Mysteries of Marine Molluscs Revealed by Chromatography
March 1st 2018The Column spoke to Kirsten Benkendorff, an Associate Professor in Environment, Science, and Engineering and the Co-Deputy Director of the Marine Ecology Research Centre at Southern Cross University in Australia, about her work investigating Muricidae molluscs, their use in ceremonial incense and traditional medicines, and the role of chromatography in this research.
Rapid Trace Analysis of Multiresidue Contaminants
January 9th 2018Mira Petrovic from the Catalan Institute for Water Research (ICRA) in Girona, Spain, reveals the advantages and practical applications of a novel method she developed for the multiresidue trace analysis of pharmaceutical compounds and their corresponding metabolites and transformation products using dual-column liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS).
The Durian Tang: Investigating the World’s Smelliest Fruit
December 5th 2017The durian fruit is notorious for its unpalatable aroma, and yet the fruit is incredibly popular throughout Southeast Asia and amongst travellers. Holding the title of “the world’s smelliest fruit” attracts attention including that of Martin Steinhaus from the Aroma Research Group at the Deutsche Forschungsanstalt für Lebensmittelchemie (German Research Center for Food Chemistry). He spoke to The Column about his group’s research into the compounds responsible for the fruit’s uniquely unpleasant aroma.
Characterizing Red Chicory Polyphenols
November 7th 2017Polyphenols are a well-known group of antioxidants widely diffused as secondary metabolites in plants, vegetables, and fruit. The Column spoke to Nicola Marchetti from the Department of Chemistry and Pharmaceutical Sciences at the University of Ferrara in Ferrara, Italy, about his research into the characterization of polyphenols in red chicory using high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS).
Analyzing Chemical Secretions in Lizards Using GC–MS/MS
November 1st 2017The chemical messages that animals use to communicate can trigger a range of responses in members of the same species. The Column spoke to Jorge Saiz from the Centre of Metabolomics and Bioanalysis (CEMBIO) at the University San Pablo CEU, Spain, about his research into the chemical secretions of lizards and the role of gas chromatography–tandem mass spectrometry (GC–MS/MS) in his work.
Characterizing Polyphenols in Food Using Chromatography
October 10th 2017There is a growing interest in polyphenols because of their noticeable antioxidant properties and their potential contribution to the defence against oxidative stress and protection against cardiovascular diseases and cancers. Oscar Núñez from the Department of Chemical Engineering and Analytical Chemistry at the University of Barcelona in Barcelona, Spain, has been working since 2010 in the analysis of polyphenols by capillary electrophoresis (CE), liquid chromatography (LC), mass spectrometry (MS), and chemometric techniques to achieve the characterization, classification, and authentication of natural products in the prevention of frauds. He recently spoke to The Column about this research.
Determining Chloride and Sugars in Food Samples Using HPLC
September 18th 2017Accurate quantification of sugars in saline solution is now possible using a new high performance liquid chromatography (HPLC) method. The Column spoke to Abdelrahman Saleh Zaky from the School of Biosciences at the University of Nottingham (Nottingham, UK) about this method.
Recent Developments in Microchip Electrophoresis
July 25th 2017Capillary electrophoresis (CE) is routinely used for chemical and biochemical analysis methods, and recently the technique has been implemented on microchips. R. Scott Martin, a professor and chair of chemistry at Saint Louis University, has been investigating ways to improve these techniques for years. He recently spoke to us about his research coupling microchip electrophoresis with electrochemical detection, coupling continuous flow with microchip electrophoresis with valving, coupling microchip CE with microdialysis sampling and electrochemistry, and more.
Unravelling the Mysteries of Glycosylation
June 20th 2017A novel quantitative method combining multiple reaction monitoring (MRM) and ultrahigh‑pressure liquid chromatography coupled to mass spectrometry (UHPLC–MS) has been developed by Carlito Lebrilla and his team to study site-specific glycosylation in manufactured recombinant monoclonal antibody drugs (rmAbs). He spoke to The Column about this research.
Intelligent Peak Deconvolution
June 6th 2017High quality, low cost is a standard mantra within the pharmaceutical industry, but with increasing structural complexity of drugs and drug candidates maintaining the core value of this mantra is becoming more difficult. Kanta Horie from Eisai Co., Ltd., recently spoke to The Column about the development of an intelligent peak deconvolution technique using multivariate curve resolution-alternating least squares (MCR-ALS) that allows accurate quantitation of multiple components with different absorbing spectra even if the peaks are not completely separated.
The Role of GC–MS in Caterpillar-Induced Plant Volatiles
May 9th 2017The Column spoke to Ashraf El-Sayed from the Plant and Food Research Institute in Lincoln, New Zealand, about his research into caterpillar-induced plant volatiles and the role of gas chromatography–mass spectrometry (GC–MS) in his work.
Investigating Cheetah Metabolite Profiles Using GC–MS
May 9th 2017Adrian Tordiffe from the Veterinary Faculty of the University of Pretoria in South Africa, is working to establish baseline metabolic profiles for captive and free-ranging cheetahs to investigate the unusual medical conditions that the animals develop in captivity. He spoke to The Column about his work and about the role that chromatography plays.
Volatile Separation: A Low-Density Approach
April 11th 2017Separating and quantifying both volatile and nonvolatile compounds in complex mixtures is a costly and time-consuming process presenting significant technical challenges. Fabrice Gritti from the Instrument, Core Research, Fundamental Group at Waters Corporation discusses his team’s unique solution to this problem, combining high-vacuum technology and low-density fluid chromatography (LDFC) with carbon dioxide as a mobile phase for a rapid and complete baseline separation of both volatile and nonvolatile compounds on a single instrument, single column, and a single run without the associated loss of resolution.
Deirdre Cabooter: LCGC’s 2017 Emerging Leader in Chromatography Award Winner
March 24th 2017Deirdre Cabooter is an emerging leader in chromatography known for her work exploring the possibilities and limitations of the kinetic plot method for comparing the kinetic performance of chromatographic separation methods and columns. Joining the University of Leuven (KU Leuven) in 2011, where she is currently an associate professor, Cabooter has continued her stellar research and taken on responsibilities in the organization of the popular symposium series HTC. She recently spoke to LCGC about her career and work so far.
Pat Sandra: LCGC’s 2017 Lifetime Achievement Award Winner
March 1st 2017Pat Sandra is known for his expansive knowledge across a wide spectrum of analytical techniques, blending the world of academia and private enterprise, and bringing separation science into the mainstream consciousness. Combining analytical excellence, innovation, and a unique gift for problem solving into a career which has lasted almost 50 years. Sandra recently spoke to LCGC about his career and work.
That Old Devil Called Tasmanian
February 7th 2017A cross-disciplinary team of researchers in Tasmania from the fields of separation science, proteomics and metabolomics, immunology and zoology are on a mission to save the Tasmanian devil from extinction using metabolic fingerprinting of serum to identify biomarkers for Devil Facial Tumour Disease (DFTD). The Column spoke to Naama Karu, Rodrigo Hamede Ross, and Richard Wilson to find out more.