Adjusting Conditions for a Routine Reversed-Phase HPLC Assay, Part I: Changing the Column


LCGC North America

LCGC North AmericaLCGC North America-12-01-2004
Volume 22
Issue 12

The authors look at two types of method modification from a scientific and regulatory standpoint: a change of column and a change in the operating system. Both are difficult to avoid if a method is used for several years.