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John Dolan has been writing "LC Troubleshooting" for LCGC for over 25 years. One of the industry's most respected professionals, John is currently a principal instructor for LC Resources, Walnut Creek, California He is also a member of LCGC's editorial advisory board.
While some variation in retention is normal, larger changes from run to run are generally indicative of a problem. Here, the auther discusses how the retention time of a peak in an LC separation can be a useful diagnostic tool to identify problems with a separation.