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Retention Time Changes
December 1, 2004
John W. Dolan
John W. Dolan
John Dolan has been writing "LC Troubleshooting" for LCGC for over 25 years. One of the industry's most respected professionals, John is currently a principal instructor for LC Resources, Walnut Creek, California He is also a member of LCGC's editorial advisory board.
LCGC North America
LCGC North America, LCGC North America-12-01-2004, Volume 22, Issue 12
While some variation in retention is normal, larger changes from run to run are generally indicative of a problem. Here, the auther discusses how the retention time of a peak in an LC separation can be a useful diagnostic tool to identify problems with a separation.