A Four-Column Approach to Developing Stability-Indicating HPLC Methods

Mazzeo,Jeffrey;Grumbach,Eric;Collier,Steven;

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A Four-Column Approach to Developing Stability-Indicating HPLC Methods

June 1, 2002

Jeffrey R. Mazzeo, Eric S. Grumbach, Steven Collier

LCGC North America

LCGC North America, LCGC North America-06-01-2002, Volume 20, Issue 6

This article describes a method development approach that uses different packing materials and mobile-phase pH levels to optimize the chromatographic separation of degradation products from active ingredients.