A Four-Column Approach to Developing Stability-Indicating HPLC Methods

Jeffrey R. Mazzeo

Eric S. Grumbach

Waters Corporation

Steven Collier

Waters Corp., 34 Maple Street, Milford, Massachusetts 01757, USA.

LCGC North America

LCGC North America, LCGC North America-06-01-2002, Volume 20, Issue 6

This article describes a method development approach that uses different packing materials and mobile-phase pH levels to optimize the chromatographic separation of degradation products from active ingredients.