HTC-19 Insights: Capillary Liquid Chromatography — Practical Considerations

James P. Grinias from Rowan University, Glassboro, New Jersey, United States, is the winner of the 2026 HTC Innovation Award, which was presented at the Hyphenated Techniques and Separations Technology (HTC-19) conference in Leuven, Belgium, on Friday, May 29, 2026. The award is co-sponsored by the HTC conference and LCGC International.

In this episode, Jim answered the following questions related to his award presentation, entitled "Advancing Miniaturized Column and Instrument Technologies for Capillary LC–MS".¹

• How do integrated capillary LC column cartridges improve ease of use and reduce setup complexity compared to traditional capillary LC systems?
• What challenges do chromatography practitioners face when working with the significantly lower mobile-phase flow rates used in capillary LC?
• In what ways can combining the column, heater, and detector into a single unit enhance analytical performance or reproducibility in miniaturized LC systems?

References

1. Grinias J.P. Advancing Miniaturized Column and Instrument Technologies for Capillary LC–MS Presented at HTC-19 2026, in Leuven, Belgium. https://htc-19.com/programme/( accessed 2026-06-04).

Biography

James P. Grinias is an associate professor of chemistry and biochemistry at Rowan University and a member of the Editorial Advisory Board (EAB) for LCGC International. His research typically focuses on the fundamental development of liquid chromatography (LC) columns in capillaries and microfluidic devices.