Hydrophilic Interaction Chromatography Using Silica Columns for the Retention of Polar Analytes and Enhanced ESI-MS Sensitivity

October 1, 2004
Bonnie Alden

,
Pamela C. Iraneta

,
Jeffrey R. Mazzeo

,
Diane M. Wagrowski-Diehl

,
Eric S. Grumbach

Waters Corporation

LCGC North America

LCGC North America, LCGC North America-10-01-2004, Volume 22, Issue 10

The use of a silica column for HILIC is examined, including mechanistic studies of analyte retention on silica in aqueous-organic mobile phases.