Using Second-Order Data in Chromatographic Analysis
LCGC Europe
The authors discuss zero-, first- and second-order data and describe the advantages of using second-order chromatographic data compared with the more traditional univariate or multivariate calibration. They demonstrate how its use can uncover much more information from chromatograms and spectra.
LC–MS/MS-Based System Used to Profile Ceramide Reactions to Diseases
April 26th 2024Scientists from the University of Córdoba in Córdoba, Spain recently used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to comprehensively profile human ceramides to determine their reactions to diseases.
High-Throughput 4D TIMS Method Accelerates Lipidomics Analysis
April 25th 2024Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.
