In this final part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor presents a case study of a high-pH separation.
|Articles|July 1, 2004
- LCGC Europe-07-01-2004
- Volume 17
- Issue 7
Molecularly Imprinted Polymers: Developments and Applications of New Selective Solid-Phase Extraction Materials
MIPs are synthetic polymeric materials possessing specific cavities designed for a target molecule. The various parameters affecting extraction selectivity are discussed in the article and the potential of MIPs as selective sorbents reviewed.
Advertisement
Articles in this issue
over 22 years ago
But I Can't Change the Methodover 22 years ago
Using Second-Order Data in Chromatographic Analysisover 22 years ago
A Question of Balance? Part 1: Principlesover 22 years ago
Farewell Csaba HorváthAdvertisement
Related to this article
Liquid chromatography–tandem mass spectrometry (LC–MS/MS) shows how processing and storage shape toxins in Nigerian rice.
Ultrahigh-pressure liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) reveals lipid shifts in acne-prone oily skin of young women.
This week, Chromatography Online.com covered the looming chromatography expertise gap, HPLC myths, steroid and biopharmaceutical separations, AI in the laboratory, and new sample extraction tools.
Gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) link tobacco leaf chemistry to cigar taste and burning.
The model context protocol (MCP) layer lets AI run mzmine mass spectrometry workflows; data stays local.
Ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) reveals a chemical imbalance behind alcohol-positive milk.
"Perspectives in HPLC" examines 5 long-held HPLC "rules" (mobile phase filtration, routine buffer use, avoiding pH near an analyte's pKa, defaulting to 4.6-mm columns, and relying on AI for early method development), showing with experimental evidence that each is conditional rather than universally true in modern small-molecule drug testing.
Advertisement
Advertisement
Trending on LCGC International
1
Conversations with Michael Dong: A Case Study of a High pH Separation
2
Advances in Biopharmaceutical Analysis EU (Oct 2026)
3
Industry Roundup: mzmine's mzassist Brings AI to Mass Spectrometry Workflows
4
Conversations with Michael Dong: Why is Mobile Phase Filtration Not Needed
5