Application Notes: LC

Use interactive calculators included in this whitepaper to determine the incremental economic value of the Agilent 1260 Infinity II Prime LC and InfinityLab LC/MSD iQ.

This application note investigates the durability of YMC’s high-strength “HG” Cyano phase under highly acidic and highly basic mobile phase conditions.

This application note details a loading study for purifying cannabidiol (CBD) from a commercially available “high-CBD” hemp oil extract.

This application note details improved HPLC assay methods for chlorhexidine gluconate on hybrid-silica and core-shell C18 stationary phases.

This application note details the development of a HPLC method for analyzing CBD and melatonin.

· The benefits of field-flow fractionation · The benefits of coupling light scattering online · Field-flow fractionation’s role in the pharmaceutical industry

· The benefits of field-flow fractionation · The benefits of coupling light scattering online · Field-flow fractionation’s role in the pharmaceutical industry

· The benefits of field-flow fractionation · The benefits of coupling light scattering online · Field-flow fractionation’s role in the pharmaceutical industry

-Proteomics based on MS is vital for biopharmaceutical research. -LC–MS instrument sensitivity has led to interest in capillary/microflow solutions. - Microchip-based pillar array chromatography offers enhanced benefits. - Microchip-based pillar array chromatography offers enhanced benefits.

- Cogent TYPE-C™ HPLC columns offer time and cost benefits to chromatographers. - These columns are suited for polar, non-polar, and water-labile compounds.

Using RSA™ glass vials virtually eliminates adsorption issue without surface treatments or vial deactivation like silanizing, which can leach into instruments and columns.

This note using YMC-Triart Bio C4 shows a robust separation at high temperatures for three commercially available mAbs: ofatumumab, palivizumab, and panitumumab.

This application note demonstrates the transfer of analytical HPLC methods from a Waters Alliance HPLC system to the Vanquish Core HPLC system.

The molecular similarity between Humira® and Yervoy® biosimilars and the corresponding innovator reference products is examined using analytical SEC, RPC and HIC.

This white paper discusses the advantages of using fast, efficient HALO® Fused-Core® Technology columns and manipulating selectivity to quickly develop methods, for fast high efficiency LC and LCMS separations.

Simple sugars ribose and xylose (are easily and quickly separated on a very stable amide column using high acetonitrile concentration in the mobile phase.

PharmaFluidics introduces a new µPAC™ capLC column that offers unprecedented performance and that given its low back pressure can be used up to flow rates of 15 µL/min.

Solid-phase extraction (SPE) is a powerful technique for LC­–MS analysis. SPE offers benefits for various solutes from a wide range of samples. Modern SPE systems can remove unwanted compounds and streamline methods.

Essential oils have been a staple of the food, fragrance, and health markets for many years. Owing to their unique composition, essential oils can be used for a variety of applications.

-How to translate methods, maximize resolution, and comply with USP -Optimizing HPLC/UHPLC method development workflows -Column coupling can provide improved sample detail and high peak capacities

- UHPLC-MS method for antibody analysis - Large-size protein separation at high temp

Multidimensional LC/MS is a powerful tool to gain info in the laboratory. Analyzing ADCs with multidimensional LC/MS provides fast data for CQAs.

A sensitive, robust method for analysis of glyphosate in wide range of foods using a simplified sample preparation procedure effective for challenging matrices

Fast and sensitive HPLC method with post-column derivatization for analyzing Fumonisins in grains and feeds at levels as low as 0.01 ug/g

A sensitive method for testing of active compounds in cannabis and cannabis-containing products.

A solution for amino acids analysis, these methods were optimized to comply with system suitability requirements of Pharmacopoeia 8.0 methods.