Application Notes: LC

· The benefits of field-flow fractionation · The benefits of coupling light scattering online · Field-flow fractionation’s role in the pharmaceutical industry

· The benefits of field-flow fractionation · The benefits of coupling light scattering online · Field-flow fractionation’s role in the pharmaceutical industry

· The benefits of field-flow fractionation · The benefits of coupling light scattering online · Field-flow fractionation’s role in the pharmaceutical industry

-Proteomics based on MS is vital for biopharmaceutical research. -LC–MS instrument sensitivity has led to interest in capillary/microflow solutions. - Microchip-based pillar array chromatography offers enhanced benefits. - Microchip-based pillar array chromatography offers enhanced benefits.

- Cogent TYPE-C™ HPLC columns offer time and cost benefits to chromatographers. - These columns are suited for polar, non-polar, and water-labile compounds.

Using RSA™ glass vials virtually eliminates adsorption issue without surface treatments or vial deactivation like silanizing, which can leach into instruments and columns.

This note using YMC-Triart Bio C4 shows a robust separation at high temperatures for three commercially available mAbs: ofatumumab, palivizumab, and panitumumab.

The molecular similarity between Humira® and Yervoy® biosimilars and the corresponding innovator reference products is examined using analytical SEC, RPC and HIC.

This white paper discusses the advantages of using fast, efficient HALO® Fused-Core® Technology columns and manipulating selectivity to quickly develop methods, for fast high efficiency LC and LCMS separations.

Simple sugars ribose and xylose (are easily and quickly separated on a very stable amide column using high acetonitrile concentration in the mobile phase.

PharmaFluidics introduces a new µPAC™ capLC column that offers unprecedented performance and that given its low back pressure can be used up to flow rates of 15 µL/min.

Solid-phase extraction (SPE) is a powerful technique for LC­–MS analysis. SPE offers benefits for various solutes from a wide range of samples. Modern SPE systems can remove unwanted compounds and streamline methods.

Essential oils have been a staple of the food, fragrance, and health markets for many years. Owing to their unique composition, essential oils can be used for a variety of applications.

-How to translate methods, maximize resolution, and comply with USP -Optimizing HPLC/UHPLC method development workflows -Column coupling can provide improved sample detail and high peak capacities

- UHPLC-MS method for antibody analysis - Large-size protein separation at high temp

Multidimensional LC/MS is a powerful tool to gain info in the laboratory. Analyzing ADCs with multidimensional LC/MS provides fast data for CQAs.

A sensitive, robust method for analysis of glyphosate in wide range of foods using a simplified sample preparation procedure effective for challenging matrices

Fast and sensitive HPLC method with post-column derivatization for analyzing Fumonisins in grains and feeds at levels as low as 0.01 ug/g

A sensitive method for testing of active compounds in cannabis and cannabis-containing products.

A solution for amino acids analysis, these methods were optimized to comply with system suitability requirements of Pharmacopoeia 8.0 methods.

Highly sensitive analysis of aflatoxins and ochratoxin A to guarantee the safety of hemp crop and hemp-containing consumer products.

An easy and sensitive method to analyze Aflatoxins B1, B2, G1, G2 and Ochratoxin A in cannabis plant and edible products at levels below established by state regulations.

A sensitive HPLC method allows analyzing cannabinoids, including THC and CBD, in hemp and hemp-containing products to ensure compliance with the 2018 Farm Bill.

This application note demonstrates the development of an SFC separation method for 46 highly polar compounds on different columns using an increased amount of modifier.

This technical overview presents the measurement of the instrument detection limit (IDL) at two different conditions of MRM dwell times.