Application Notes: LC

This study investigates the capabilities of asymmetrical flow field-flow fractionation coupled with MALS for the detection of carbon nanotubes in soot and soil.

The applicability of AF4-UV-MALS for sizing and quantification of adeno-associated virus (AAV) samples with different degrees of aggregation is presented.

This study investigates the capabilities of asymmetrical flow field-flow fractionation coupled with MALS for the detection of carbon nanotubes in soot and soil.

This study demonstrates the combination of inverse supercritical fluid extraction and miniaturized AF4-MALS for the analysis of nanoparticles in commercial sunscreens.

This study demonstrates the combination of inverse supercritical fluid extraction and miniaturized AF4-MALS for the analysis of nanoparticles in commercial sunscreens.

This study describes the analysis of PLGA particles under physiological conditions using centrifugal field-flow fractionation coupled with dynamic light scattering.

This study describes the analysis of PLGA particles under physiological conditions using centrifugal field-flow fractionation coupled with dynamic light scattering.

This study describes the separation of nanoplastics and determination of their surface charge by electrical asymmetrical flow field-flow fractionation.

This study describes the separation of nanoplastics and determination of their surface charge by electrical asymmetrical flow field-flow fractionation.

This application note presents the characterization of ribosomal RNA using asymmetrical flow field-flow fractionation coupled with multi-angle light scattering.

Electrical asymmetrical flow field-flow fractionation coupled with MALS was used to characterize the NIST monoclonal antibody reference material 8671.

This application note presents the characterization of ribosomal RNA using asymmetrical flow field-flow fractionation coupled with multi-angle light scattering.

This study describes the characterization of metal-containing nanoparticles in tattoo ink using AF4 coupled with multi-angle light scattering and ICP-MS.

This study describes the characterization of metal-containing nanoparticles in tattoo ink using AF4 coupled with multi-angle light scattering and ICP-MS.

Avoid precipitation of concentrated samples by splitting the pump channels: organic phase will pass through the autosampler; aqueous phase will join at the column head.

Avoid precipitation of concentrated samples by splitting the pump channels: organic phase will pass through the autosampler; aqueous phase will join at the column head.

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This application note shows how to achieve higher recoveries for commercially available MAbs using 15 % isopropanol as modifier in HIC mode.

μPAC™ technology has been used for analysing HCP impurities originating from recombinant expression systems used in the production of mAb based biotherapeutics.

The landscape for new biological drug development continues to evolve in complexity. With biosimilars entering the market and originator products coming off patent, the competitive race for market dominance is reliant on!

The landscape for new biological drug development continues to evolve in complexity. With biosimilars entering the market and originator products coming off patent, the competitive race for market dominance is reliant on!

In this application we show how to achieve the best separation and sensitivity for insulin UHPLC-MS analysis by using formic acid as a weak ion pairing agent.

This application note shows how to achieve higher recoveries for commercially available MAbs using 15 % isopropanol as modifier in HIC mode.

The analysis of intact MAb and their fragments using the UHPLC compatible YMC-Pack Diol-200 column and specifically designed YMC-SEC MAB column is described.

The effective separation of intact antibodies from ADCs with their single DARs using hydrophilic interaction chromatography linked to UV/Vis is shown.

This application note demonstrates how to achieve robust chromatographic results for commercially available MAbs with higher sensitivity and sharper peaks at 80°C.

In addition to existing RP based methods, a method is presented for the determination of oligonucleotides using YMC’s strong, non-porous anion exchanger BioPro IEX QF.