Application Notes: Pharmaceuticals

Due to the highly polar nature of saccharides, the analysis of sugars is typically achieved using hydrophilic interaction chromatography (HILIC).

Organic arsenic compounds added to feed stocks of chicken and poultry pose serious environmental and ecological threats. National and worldwide health organizations, such as the United States Environmental Protection Agency and the US Food and Drug Administration, have recently implemented more stringent concentration limits for arsenic species in drinking water and foodstuffs.

The global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population.

In brewing, barley undergoes a malting process, the grain if first drenched to make it germinate and then dried in kilns to capture the sugar and flavor compounds for the brewing process.

Pain management LC analyses can be difficult to optimize due to the limited selectivity of C18 and phenyl-hexyl phases.

Poly(lactic-co-glycolic acid) (PLGA) is a copolymer based on glycolic acid and lactic acid. The two monomer units are linked together by ester linkages and form linear polyester chains

CAPCELL CORE ADME S2.7 (ADME) is a column packed with a novel stationary phase of superficially porous silica (core shell particle) modified by adamantyl functional groups.

The challenging retention of polar organic acids in reversed phase conditions is accomplished using a unique multi-mode stationary phase.

Reflectron lenses are used in time-of-flight (TOF) mass spectrometers to create an electrostatic field to alter ion flow, providing for a longer flight path and therefore greater resolution.

Gel filtration chromatography (GFC) is a powerful analytical tool in the separation of antibodies. Traditionally, GFC columns with a dimension of 7.8 mm i.d. × 30 cm are used for analytical purposes.

Organochlorine pesticides are among the more notorious organic pollutants. Gaining wide spread attention into the latter part of the 20th century, and ultimately leading to their ban, OCPs remain with us as a legacy contaminant in the environment.

US EPA wastewater method 624 Purgeables was originally published as 40 CFR Part 136 Appendix A in the mid 1980s.

Vicinal diketones (VDKs) are naturally produced compounds in the fermentation process. The monitoring of VDK levels is of great importance as the concentration of these compounds can greatly alter the flavor of a beverage.

B vitamins are a group of water soluble vitamins that play an important role in cell metabolism. This group consists of a number of compounds including thiamine (vitamin B1), riboflavin (vitamin B2), niacin and nicotinamide (vitamin B3), and pyridoxine and pyridoxal (vitamin B6).

Lactulose, a semi-synthetic disaccharide, is a useful indicator for heat induced modifications in milk. Lactulose can be derived from lactose by alkaline isomerization or enzymatic transgalactosylation of fructose.

Direct exposure probe (DEP) coupled to the Pegasus HT, time-of-flight mass spectrometer, was used for the identification of synthetic cannabinoids in MTN-series compounds.

Mobile phase pH is a powerful tool in methods development, particularly for separation of neutral forms of amines or other organic bases under alkaline conditions.

Photonis has combined two of our superior detection and analysis technologies into a new digital ion beam profiling unit. The new Ion Beam Profiler combines a large microchannel plate (up to 120 mm) in a complete assembly with the Photonis Nocturn, a high-resolution digital CMOS low-light camera which is immune to sudden light damage.

Silica-based cyano stationary phases have historically exhibited poor stability and short column lifetime at pH extremes. This application note details an investigation of the stability of YMC's Cyano-HG (high strength) 10 ?m silica-based stationary phase, which was performed at a customer's request.

In recent years, the increasing cost and uncertain availability of helium have prompted many labs to explore the use of hydrogen as an alternate carrier gas.

Carbendazim is a widely used, broad-spectrum fungicide to control mold on citrus crops.

Polypeptide hormones play key endocrine functions in humans. In particular, angiotensins are oligopeptide hormones, critical in the regulation of body fluids which ultimately affect blood pressure levels in individuals.

The use of mass spectrometry as a means of detection is becoming increasingly more common among research laboratories in the field of proteomics.

Due to the highly polar nature of saccharides, the analysis of sugars is typically achieved using hydrophilic interaction chromatography (HILIC).

Organic arsenic compounds added to feed stocks of chicken and poultry pose serious environmental and ecological threats.

USP assay methods are widely used for quality control and stability testing.

Organophosphate pesticides (OPPs) are widely used globally for agricultural pest control.

The European Pharmacopoeia (Ph. Eur.) defines requirements for the qualitative and quantitative composition of medicines, as well as the tests to be carried out on medicines and on substances and materials used in their production.