Application Notes: Pharmaceuticals
Characterization of mAb Glycoforms on FcγRIIIA-Ligand by Analytical and Semi-Preparative Chromatography
To monitor FcR receptor binding, a recombinant FcγRIIIa-ligand has been commercialized into TSKgel FcR-IIIA high-performance affinity chromatography (AFC) columns that separate antibodies based on affinity differences to FcγRIIIa.
Analysis of Long-Chain Oligo-DNA with the Shodex™ VN-50 2D HILIC Column
This technical article outlines the analysis of long-chain oligonucleotides utilizing a simple eluent containing acetonitrile with a relatively low level of salt and no ion-pair reagent.
Reversed Phase Flash Chromatography Purification of Peptide-Peptoid Hybrids
Purification of peptide-peptoid hybrids can be obtained by reversed phase chromatography with excellent recovery and resolution.
Improved Compound Recovery with ELSD Systems
The ability to collect compounds is directly related to the ability to detect them. Many compounds possess weak or non-existent chromophores which causes UV detection to exhibit poor yields.
Quality Control of Lipid-Based Formulations by HPTLC
This methodology demonstrates an efficient approach for identity and stability testing of lipids and lipid-based formulations like mRNA vaccines by HPTLC.
Isolation of Paclitaxel
The fight against cancer employs many tools. Paclitaxel, a compound found in the bark of the Pacific yew tree, is one that that has been found to make a big difference.
Analysis of e-liquids According to ISO 20714
In this application note we demonstrate the excellent performance of Sapiens-624MS columns for the analysis of e-liquids based on ISO 20714
Rapid Separation of Basic Drug Compounds Under Alkaline pH Conditions
The PRP–C18 isolates structurally diverse pharmaceutical compounds in under 6 min using basic solutions.
Application Note: LC–MS/MS Solution for Quantitation of Nitrosamine Impurities in Metformin
This application note demonstrates robust, sensitive quantitation of 10 nitrosamines, and the use of the LC–SRM-MS method to quantify nitrosamine impurities in metformin.
Application Note: HRAM LC-MS Method for the Determination of Nitrosamine Impurities
This application note demonstrates fast, highly sensitive quantitation of nine nitrosamines, and the use of the LC–MS method to measure nitrosamine.