A high performance liquid chromatography–ultraviolet (HPLC–UV)-based method was recently developed for the quantification of selpercatinib in human plasma, an advance that may lead to the reduction of adverse events as well as an optimization of efficacy.
Researchers measured bovine tooth enamel samples with colorimetry, high-performance liquid chromatography (HPLC), and ultraviolet-visible (UV-Vis) spectrophotometry to develop a comprehensive understanding of coffee-induced tooth discoloration by examining the individual and combined effects of CGA and pigments and determining how their concentrations are affected by coffee roast level.
A recent study investigating the association between dietary polyunsaturated fatty acid (PUFA) intake and estradiol levels in women in the United States utilized isotope dilution liquid chromatography–tandem mass spectrometry to measure serum estradiol levels.
Using a solid phase microextraction gas chromatography-mass spectrometry (SPME GC-MS)-based metabolomics approach, a recent study by the School of Life Sciences and Technology at Institut Teknologi Bandung (Indonesia) investigated the impact of environmental factors (including temperature, rainfall, and altitude) on volatile metabolite profiles of Robusta green coffee beans from West Java.
LCGC International sat down with Christopher Kozak, a professor at Memorial University to speak about his recent research using MALDI-TOF analysis to identify unknown blobs in Newfoundland, Canada’s Placentia Bay.
Researchers showed that a 12-week aerobic exercise regimen reduced circulating branched-chain amino acid levels in obese mice while attenuating insulin resistance.
Researchers used high performance liquid chromatography and untargeted metabolomics by Fourier-transform ion cyclotron resonance-mass spectrometry to highlight the critical role of root exudates in drought tolerance.
A recent study identified and quantified anthocyanin (which are known for their antioxidative properties and potential effectiveness against depression) in blueberries, blackberries, black mulberries, and cranberries using ultra high-pressure liquid chromatography (UHPLC) followed by in vivo evaluation of their antidepressant-like activities.
A recent study measured stress and reproductive hormones in three stocks of free-ranging bottlenose dolphins inhabiting different natural salinities across the Gulf of Mexico, with hormones extracted from the blubber of 82 remotely biopsied dolphins and quantified using ultrahigh-pressure liquid chromatography (UHPLC) coupled with orbital ion trap fusion mass spectrometry.
“Strange blobs” that started washing up on Newfoundland’s shores months ago may have been identified through a Canadian chemist’s investigation using mass spectrometry (MS).
After collecting dried blood spots from preterm infants with gestational age (GA) of less than 32 weeks within 24 hours after birth, researchers used liquid chromatography-tandem mass spectrometry (LC–MS/MS) to perform targeted measurements of metabolites to identify differential metabolites in preterm infants with bronchopulmonary dysplasia and uncovering circulating biomarkers for the early prediction of this chronic lung disease.
Aiming to develop a comprehensive strategy for evaluating the chemical migration from various reusable plastic bottles, researchers from the University of Copenhagen utilized vacuum evaporation concentration (VEC) enrichment combined with liquid chromatography (LC) high resolution mass spectrometry (HRMS) analysis to investigate a wide range of materials from different manufacturers to identify those with higher and lower chemical migration rates.
A recent study evaluated the potential of fruit by-products from acerola, guava, and tamarind’s potential in producing fermented beverages, with their acid profiles determined by high performance liquid chromatography (HPLC).
A recent study set out to assess the significance of geographical and varietal factors in the content of alkaloids, phenolic compounds, and the antioxidant capacity of chocolate samples. Filtered extracts were analyzed by reversed-phase high-performance liquid chromatography (RP-HPLC) with ultraviolet (UV) and spectrophotometric methods to determine individual phenolics and overall indexes of antioxidant and flavonoid content.
Liquid chromatography and tandem mass spectrometry (LC–MS/MS) was used to show that repeated stress can cause delayed but sustained changes in blood plasma proteins associated with water conservation, immune responses, fat metabolism, insulin sensitivity, iron recycling, and hormone transport in elephant seals. Some of these changes may be novel markers of recent and chronic stress exposure in marine mammals.
LCGC International spoke to Heather Barkholtz and Maia Bates of the University of Wisconsin-Madison about their recent evaluation of a broad screening technique for high-priority drugs of abuse in whole blood.
A recent study investigated the protein composition and baking quality of 14 German common wheat landraces, with 6 modern varieties serving as a control group. The protein composition was determined using modified Osborne fractionation and reversed-phase high-performance liquid chromatography (RP-HPLC).
A recent study examined the impurity profile of thirteen different lots of synthetic nicotine and compared them to fourteen lots of nicotine extracted from plants using in-house analytical methods, with samples tested for alkaloids and phenols with reversed-phase high-performance liquid chromatography (RP-HPLC).
The aroma properties of spontaneously fermented Cabernet Sauvignon wines produced from seven sub-regions of Shangri-La, China were comprehensively analyzed using the headspace micro-extraction with gas chromatography-mass spectrometry (GC-MS), odor activity values, and olfactory evaluation.
On the suggestion that per- and polyfluoroalkyl substances (PFAS) affect both lactation and the human metabolome, perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were measured in the milk of 425 participants from the New Hampshire Birth Cohort Study using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
A recent study compared different workflows for extracting, purifying, and analyzing bone proteins using liquid chromatography with tandem mass spectrometry (LC–MS/MS), including an in-StageTip protocol previously optimized for forensic applications, and two protocols using novel suspension-trap technology (S-Trap) and different lysis solutions. LCGC International discussed this work with Noemi Procopio of the School of Law and Policing and the Research Centre for Field Archaeology and Forensic Taphonomy at the University of Central Lancashire (UK), corresponding author of the paper that resulted from this study.
In this “Equipment Roundup,” the editors of LCGC International present SCIEX’s ZenoTOF 7600+ System and Fraunhofer Institute for Integrated Circuits’ nanoSPECTRAL chip.
Ultra-high performance liquid chromatography, coupled with a fluorescence detector, was used in a recent study to profile 23 amino acids and glutathione in juices of four internationally relevant grape varieties grown under different soil and climatic conditions.
A recent study analyzed the variability in plasma quinidine (QND) concentrations using population pharmacokinetics to determine an effective and safe dosage regimen for Thoroughbred horses suffering from atrial fibrillation (AF).
An investigation of the accumulation of primary and secondary metabolites, including bioactive compounds, to characterize the qualitative traits of blood oranges at the time of harvest was conducted, with liquid chromatography identifying and quantifying simple sugars, and spectrophotometric analysis identifying and quantifying organic acids, polyphenols, and flavonoids.
LCGC International recently spoke to Tomáš Rozsypal of the Nuclear, Biological and Chemical Defence Institute of the University of Defence (Vyskov, Czech Republic) about his work utilizing gas chromatography in researching the persistence of A-234 nerve agent on indoor surfaces, and the paper that resulted from it.
In a recently published study, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was used to analyze 100 Turkish apple samples for the presence of 225 different pesticide residues during the 2022-2023 harvest season.
Gas chromatography (GC) was used to investigate the genetic basis of olive oil quality by comparing the transcriptome of two Iranian cultivars with contrasting oil profiles.
For the first time, the effectiveness of select fluorinated sorbents in the isolation of 15 PFAS compounds of different classes, compared to non-fluorinated sorbents, on solid-phase microextraction (SPME) fiber geometry was investigated.
In this “Equipment Roundup,” the editors of LCGC International present MOBILion’s novel high resolution mass spectrometry (HRMS) functionality and Agilent’s InfinityLab LC Series portfolio.
