Michael Bartlett, Torgny Fornstedt and Mark Dickman conclude the series with their expert insights into what the future of oligonucleotide analysis could involve.
Michael Bartlett
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Over the past 30 years at the University of Georgia, Michael Bartlett’s group has been involved in the development, validation and implementation of novel bioanalytical methodologies to advance biomedical research. His laboratory works broadly in the areas of drug discovery, development and toxicology, resulting in over 195 peer-reviewed publications in a wide variety of areas. They have studied many aspects involved in the use of LC–MS to evaluate therapeutic oligonucleotides for quality control, bioanalysis, pharmacokinetics and metabolism. They have also adapted many of these approaches to analyze microRNAs as potential disease biomarkers.
Articles by Michael Bartlett
The panel discuss the innovations in sample preparation that are being developed for oligonucleotide analysis.
The sensitivity and selectivity of high resolution mass spectrometry (HRMS) for oligonucleotide analysis is discussed.
The panel explore the unique challenges associated with analysing double- stranded oligonucleotide products and oligonucleotides with higher-order structures.
Mark Dickman shares his views on analyzing larger oligonucleotides, including mRNAS.
The panel explore the potential of multidimensional chromatography for the analysis of oligonucleotides.
Torgny Fornstedt describes how machine learning can work in practice for oligonucleotide analysis.
The panel discuss the role of ion-exchange chromatography (IEX) and hydrophilic interaction liquid chromatography IHILIC) in oligonucleotide analysis, and if these techniques could challenge ion-pair reversed-phase high performance liquid chromatography (IP-RP-HPLC) in the near future.
Michael Bartlett, Torgny Fornstedt and Mark Dickman elaborate on the possible reasons why ion-pair reversed-phase high performance liquid chromatography (IP-RP-HPLC) has risen to such prominence for the separation of oligonucleotides.
The panelists introduce themselves and outline their practical experience and knowledge of oligonucleotides, setting the stage for an illuminating discussion on current challenges, solutions and innovations in this ten-part panel discussion series organised by LCGC International in collaboration with the Chromatographic Society (ChromSoc).
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Latest Updated Articles
Analyzing Oligonucleotides With Higher Order StructuresPublished: October 22nd 2025 | Updated: October 23rd 2025
The Pros and Cons of Multidimensional Chromatography for Oligonucleotide AnalysisPublished: October 21st 2025 | Updated:
- Analyzing Oligonucleotides With Higher Order Structures
Published: October 22nd 2025 | Updated: October 23rd 2025
Machine Learning for Oligonucleotide Analysis in PracticePublished: October 21st 2025 | Updated: October 21st 2025
- The Role of IEX and HILIC for Oligonucleotide Analysis
Published: October 21st 2025 | Updated:
Meet The PanelistsPublished: September 30th 2025 | Updated:
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