Analyzing Oligonucleotides With Higher Order Structures

When working with oligonucleotides, complexity can significantly impact performance and reliability. Double-stranded products and sequences with higher-order structures present unique challenges in synthesis, handling, and application. These structural features can affect stability, hybridization, and even downstream results. In this video, we explore the specific hurdles researchers face when working with these types of oligonucleotides—and how to overcome them. Catch the discussion in the video above.